Liste des Publications[ Kasséhin Urbain C.]

N,ndimethylformamide.diiodine complex (dmf.i2) as an innovative efficient green catalyst in the synthesis of thiosemicarbazones by condensation of ketones with thiosemicarbazides

Article, Ajoutée le 17/01/2017 10:11

In a drug discovery program aimed at finding new anti-trypanosomal drugs, we developed the N, Ndimethylformamide.diiodine complex (DMF.I2) as an innovative and efficient green catalyst for the condensation reaction of aldehydes/ketones with arylthios [...]

KASSÉHIN URBAIN C. [1], GBAGUIDI FERNAND A. [2], MCCURDY CHRISTOPHER R. [3], POUPAERT JACQUES H. [4],

Insight into the diels-alder reaction: a green chemistry revisitation of the synthesis of a cantharidine-like trypanocidal pilot-molecule

Article, Ajoutée le 17/01/2017 10:25

Relying on a straightforward « Green-Chemistry » based approach, this article reports an optimized Diels-Alder (DA) experimental set-up allowing for this reaction to be cleanly operated in the presence of water used both as solvent and catalyst. Thi [...]

GBAGUIDI A. FERNAND [1], KASSÉHIN URBAIN C. [2], PREVOST JULIEN R. C. [3], FREDERICK RAPHAËL [4], MCCURDY CHRISTOPHER R. [5], POUPAERT JACQUES H. [6],

A concise synthesis of 2-(1,2,3,4-tetrahydro-6-methoxynaphthalen-4-yl) ethanamine, a key intermediate in the elaboration compound library of agomelatine analogs

Article, Ajoutée le 17/01/2017 10:32

Agomelatine, a melatonin-like antidepressant drug based on a naphthalene scaffold, has received considerable attention these last twenty years. This drug molecule undergoes important liver first pass effect and suffers therefore of a short plasma hal [...]

KASSÉHIN URBAIN C. [1], GBAGUIDI A. FERNAND [2], MCCURDY CHRISTOPHER R. [3], POUPAERT JACQUES H. [4],

Trypanocidal activity of a thioacyl-thiosemicarbazide derivative associating both immunostimulating thalidomide and anti-parasitic thiosemicarbazide pharmacophores

Article, Ajoutée le 17/01/2017 10:54

African trypanosomiasis remains a life-threatening disease and there is nowadays an urgent need for improved therapeutic agents for this pathology. In this context, in order to create novel anti-protozoa prototype containing both a trypanocidal thios [...]

KASSÉHIN URBAIN C. [1], GBAGUIDI A. FERNAND [2], MCCURDY CHRISTOPHER R. [3], POUPAERT JACQUES H. [4],

Synthesis and trypanocidal activity of salicylhydrazones and p-tosylhydrazones of s-(+)-carvone and arylketones on african trypanosomiasis

Article, Ajoutée le 17/01/2017 11:06

Hydrazones are nowadays considered to be good candidates for various pharmaceutical applications. Here, we have synthesized two series of hydrazones: salicylhydrazones (GS1-4) and p-tosylhydrazones (GT1-4) from S(+)-carvone and three aryketones with [...]

GLINMA BIENVENU [1], GBAGUIDI A. FERNAND [2], KASSÉHIN URBAIN C. [3], KPOVIESSI DOSSOU SIKA SALOMÉ [4], HOUNGBEME ALBAN [5], HOUNGUE HORRHUS D. [6], ACCROMBESSI GEORGES C. [7], POUPAERT JACQUES H. [8],

Synthesis of antitrypanosomal thiosemicarbazones using anthranilic acid as an innovative green nucleophilic catalyst

Article, Ajoutée le 17/01/2017 11:37

Trypanosomiasis constitutes a severe health problem for sub-saharian African and latin American population and there is an urgent need for better drugs to cure this life-threatening disease. In this context, aromatic thiosemicarbazones appears attrac [...]

KASSÉHIN URBAIN C. [1], GBAGUIDI A. FERNAND [2], MCCURDY CHRISTOPHER R. [3], POUPAERT JACQUES H. [4],

Synthesis and antiepileptic activity assessment of 5-benzoyloxindole, a novel phenytoinergic template

Article, Ajoutée le 18/01/2017 09:01

Based on a rational approach using merely bioisosterism as euristic tool, we designed and tested a short series of congeners of 6-benzoyl-2(3H)-benzoxazolone as phenytoinergic lead. Among them, 5-benzoyloxindole showed an impressive activity in the M [...]

KASSÉHIN URBAIN C. [1], GBAGUIDI A. FERNAND [2], CARATO PASCAL [3], MCCURDY CHRISTOPHER R. [4], POUPAERT JACQUES H. [5],

Electronic and steric effects in the control of the anilinium chloride catalyzed condensation reaction between aldones and 4-phenylthiosemicarbazide

Article, Ajoutée le 18/01/2017 10:44

A concise series of aldehydes and ketones were reacted in a condensation reaction with 4phenylthiosemicarbazide in order to assess the relative influence of the steric and electronic effects in the control of this reaction. While steric effects had a [...]

KASSÉHIN URBAIN C. [1], GBAGUIDI A. FERNAND [2], KAPANDA COCO N. [3], MCCURDY CHRISTOPHER R. [4], BIGOT ANDRÉ K. [5], POUPAERT JACQUES H. [6],

Publications par entité

  • Centre de Formation et de Recherche en matière de Population (CEFORP) (0)
  • Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable (CIFRED) (0)
  • Chaire Internationale en Physique Mathématique et Applications (CIPMA-Chaire UNESCO) (0)
  • Ecole Nationale d'Administration et de Magistrature (ENAM) (0)
  • Ecole Nationle d'Economie Appliquée et de Management (0)
  • Ecole Normale Supérieure (0)
  • Ecole Polytechnique d'Abomey-Calavi (EPAC) (0)
  • Faculté de droit et de Science Politique (FADESP) (0)
  • Faculté des Lettres et Sciences Humaines (FLASH) (0)
  • Faculté des Sciences Agronomiques (0)
  • Faculté des Sciences de la Santé (FSS) (0)
  • Faculté des Sciences Economiques et de Gestion (FASEG) (0)
  • Faculté des Sciences et Techniques (FAST) (0)
  • Faculté des Sciences Humaines et Sociales (FASHS) (0)
  • Institut de Formation et de Recherche en Informatique (IFRI) (0)
  • Institut de Mathématiques et de Sciences Physiques (IMSP) (0)
  • Institut National de l'Eau (INE) (0)
  • INSTITUT NATIONAL DE LA JEUNESSE DE L’EDUCATION PHYSIQUE ET SPORT(INJEPS) (0)
  • Institut National des Métiers d'Art d'Archéologie et de la Culture (INMAAC) (0)
  • Institut Régional de Santé Publique (IRSP) (0)

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