Publications Scientifiques

[ Article ] Survey of air pollution in Cotonou, Benin-air monitoring and biomarkers

Date de soumission: 23-02-2018
Année de Publication: 2006
Entité/Laboratoire Laboratoire de Biochimie et de Biologie Moléculaire (LBBM)
Document type : Article
Discipline(s) : Biochimie, biophysique & Biologie Moléculaire
Titre Survey of air pollution in Cotonou, Benin-air monitoring and biomarkers
Auteurs Ayi-Fanou Lucie [1], Mobio Théophile A. [2], Creppy Edmond [3], Fayomi Benjamin [4], SANNI AMBALIOU [0],
Journal: Science of the Total Environnement
Catégorie Journal: Internationale
Impact factor: 3.286
Volume Journal: 358
DOI:
Resume Exposure to genotoxic compounds present in ambient air has been studied in Cotonou, Benin, a city where two-stroke motorbikes are the major form of transportation and gasoline quality is poor. Personal monitoring and biomarkers were used to assess the exposure. Non-smoking taxi-moto drivers (city) and village residents were the study subjects. Benzene exposure was significantly higher in the city, as compared to the village (76.0 ± 26.8 μg/m3 versus 3.4 ± 3.0, p = 0.0004). Urinary excretion of benzene and S-phenylmercapturic acid (S-PMA) were also highest in subjects living in the city, whereas 1-hydroxypyrene was not different. The level of total polycyclic aromatic hydrocarbons (PAHs), associated with particles, ranged from 76.21 to 103.23 in Cotonou versus 1.55 ng/m3 for the village. Determination of DNA damage in lymphocytes showed that subjects from the city had elevated number of lesions compared to subjects in the village in terms of bulky DNA adducts, 8-hydroxy-2′-deoxyguanosine and 5-methylcytosine, whereas DNA fragmentations analysed by alkaline gel electrophoresis was not different between the subjects. In conclusion, this study shows that air pollution is pronounced in Cotonou, Bénin and is associated with elevated levels of DNA damage in residents of the city compared to people living in a non-polluted rural village.
Mots clés Ambient air Polycyclic aromatic hydrocarbons Benzene DNA damage Biomarker
Pages 85 - 96
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