A high yield synthesis of phenytoin and related compounds using microwave activation
Article, Ajoutée
le 26/01/2017 09:54
A reaction system is described to synthesize phenytoin, a major antiepileptic drug, and structurally related compounds using a two-step approach. The first step involves the treatment of a benzil derivative by thiourea in dimethylsulfoxide (DMSO) i [...]
GBAGUIDI A.FERNAND [1], KPOVIESSI SALOMÉ S. D. [2], KAPANDA COCO N. [3], MUCCIOLI GIULIO G. [4], LAMBERT DIDIER M. [5], ACCROMBESSI GEORGES C. [6], MOUDACHIROU MANSOUROU [7], POUPAERT JACQUES H. [8],