| Titre |
Spasmolytic effects of aqueous extract of mixture from Aframomumummelegueta(K Schum) – Citrus aurantifolia (Christm and Panzer) on isolated trachea from Rat |
| Auteurs |
AHOUNOU FIFAMIN JUDITH [1],
Ouédraogo Géofroy [2],
GBENOU J. [3],
Ouédraogo Sylvin [4],
AGBODJOGBE WILFRID [5],
DANSOU HOUNDJOVI PIERRE [6],
MOUDACHIROU MANSOUROU [7],
|
| Journal: |
Afr. J. Tradit,.Complemenary. Altern. Med., 2012 |
| Catégorie Journal: |
Internationale |
| Impact factor: |
0.7 |
| Volume Journal: |
9 |
| DOI: |
ISSN : 0189-6016 www.ajol.info/index.php/ajtcam journals.sfu.ca/africanem/index.php/ajtcam |
| Resume |
The spasmolytic properties of the aqueous extract of Aframomum melegueta (K Schum) and Citrus aurantifolia
(Christm and Panzer) (AMCA) mixture were tested on isolated rat trachea. Inhibition of the contraction was observed the in
presence of the AMCA (EC 50 = 1.80 ± 0.48 mg/mL) after a pre contraction of the trachea by acetylcholine (10 -5 M). With
propranolol (10 -6 M), the spasmolytic activity of the mixture was inhibited and the concentration-response curve shifted to the
right. The EC50 value was then 2.60 ± 0.41 mg/mL. AMCA also inhibited contraction induced by KCl (4.10 -2 M) with EC50
value = 1.86 ± 0.65 mg/mL. These results clearly show the relaxing effect of the aqueous extract on the isolated rat trachea. This
effect involved some β-adrenergic receptor inhibition. |
| Mots clés |
Key words: Aframomum melegueta; Citrus aurantifolia; extract; bronchodilatory; spasmolytic, Rat trachea. |
| Pages |
228 - 232 |
| Fichier |
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