| Titre |
Antimycobacterial screening of plants from Benin on Mycobacterium ulcerans, the causal agent of Buruli ulcer |
| Auteurs |
YEMOA Loconon Y. Achille [1],
MARTIN M [2],
AFFOLABI DISSOU [3],
Gbénou Joachin [4],
MANSOUROU Moudachirou [5],
BIGOT KOFFI ANDRÉ [6],
ANAGONOU-YEHOUENOU SEVERIN [7],
PORTAELS Françoise [8],
Quetin-Leclercq Joëlle [9],
|
| Journal: |
West African Journal of Research for Health |
| Catégorie Journal: |
Africaine |
| Impact factor: |
0 |
| Volume Journal: |
3 |
| DOI: |
|
| Resume |
The purpose of this study is to investigate
the antimycobacterial activity against Mycobacterium
ulcerans of plants used in traditional medicine in Benin
to treat Buruli ulcer (BU). Out of 49 plants identified,
44 were selected and screened. Crude extracts
of leaves, fruit seeds, and roots were prepared and
the minimum inhibitory concentration (MIC) values
were determined using an adapted Resazurin
Microtiter Assay (REMA). The crude extracts of
Holarrhena floribunda (G.Don) T. Durand and Schinz
and Jatropha curcas Linn showed inhibitory activity
against M. ulcerans at concentrations of 125 and 250
μg/ml respectively. The adapted REMA method
used in this study to determine the MIC values of
natural product is simple, sensitive, and rapid, and
could be a method of choice to successfully assess
antibacterial properties of plants extracts against
M. ulcerans. This can also contribute to document
traditional treatment of BU. |
| Mots clés |
Buruli ulcer; Traditional medicine; Medicinal
plants; Antimycobacterial activity; Benin. |
| Pages |
15 - 18 |
| Fichier |
(PDF) |