Publications Scientifiques

[ Communication ] High Risk HPV genotypes in the south of Benin and lack of association with cervical dysplasia: a decade investigation

Date de soumission: 22-01-2021
Année de Publication: 2018
Entité/Laboratoire Laboratoire de Biochimie et de Biologie Moléculaire (LBBM)
Document type : Communication
Discipline(s) : Biochimie, biophysique & Biologie Moléculaire
Titre High Risk HPV genotypes in the south of Benin and lack of association with cervical dysplasia: a decade investigation
Auteurs
Conference: Journées Scientifiques Internationales de Lomé, XVIII ème Edition
Lieu Conference:
Volume: 18
DOI:
Mots clés Incidence, high risk human papilloma virus, infection, cervical dysplasia.
Resume ACT Introduction: High Risk Oncogenic Human Papillomavirus (HR-HPV) are accountable for 7.7% of cancers in developing countries, mainly cervical cancer. In Benin, HR-HPV infection in women triggered nearly 781 new cases of cervical cancer each year leading to 616 (79%) deaths. Current vaccines may not cover all HR-HPV genotypes encountered in west Africa including Benin. The objective of our study was to determine HR-HPV genotypes in the South Benin to launch regional HPV mapping associated to cervical dysplasia. For this purpose, HR-HPV genotypes from 2017 was compared to HPV genotypes from 2007 in the south of Benin to evaluate HR-HPV trend over a decade along with associated cervical dysplasia. Methods: retrospective comparative analysis was carried out on HR-HPV genotypes of cervical uterine swab (CUS) samples in 2017 (n= 234) and 2007 (n=385). In 2017 real-time multiplexed PCR was used while in 2007 traditional nested polymerase chain reaction (PCR) was used while. In both cases screening of cervical precancerous and cancerous lesions (dysplasia) was performed by colposcopy subsequently to vaginal application of acetic acid (VIA) and Lugol’s iodine solution (VILI). Results: The prevalence of HPV infected women in 2017 was 80/234 (34%) with 30 coinfections. HR-HPV count was 125 of which the most frequents were HPV52 with 20/125 (16%), HPV58 13/125 (10%), HPV51 11/125 (9%), HPV66 10/125 (8%), HPV68 10/125 (8%), HPV35 10/125 (8%), HPV45 10/125 (8%), HPV18 8/125(6%), HPV16 (1.6%) and HPV33 (1.6%). No correlation was observed between HR-HPV and cervical dysplasia; VIA and VIII positive were observed in 5.55% (13/234) and 6.83% (16/234) women. In 2007 the prevalence of women infected with HR-HPV was 85/385 (22.07%) with 18 co-infections. Common HPV genotypes found were HPV 35 (14.28%), HPV31 (13.33%), HPV66 (13.33%), HPV68 (13.33%), HPV58 (10.47%), HPV52 (8.57%), HPV51 (7.61%), HPV18 (6.66%), HPV45 (5.71%), HPV16 (3.80%) and HPV33 (3.80%). Discussion and Conclusion: Although upsurge of HR-HPV infection appears within a decade in the south of Benin, genotypes observed were not all targeted by current vaccines. Thus, most common HR-HPV in west African women should be taken into consideration prior to large scale population-based vaccination.
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