Publications Scientifiques

[ Communication ] Deficiency of lymphocyte differentiation transcription factor GATA3 in sick children may influence disease outcome.

Date de soumission: 22-01-2021
Année de Publication: 2017
Entité/Laboratoire Laboratoire de Biochimie et de Biologie Moléculaire (LBBM)
Document type : Communication
Discipline(s) : Biochimie, biophysique & Biologie Moléculaire
Titre Deficiency of lymphocyte differentiation transcription factor GATA3 in sick children may influence disease outcome.
Auteurs
Conference: 3ème Journée Scientifiques du CAMES (JSDC-3), Université Félix Houphouët Boigny
Lieu Conference: Université Félix Houphouët Boigny, COTE D'IVOIRE
Volume: 3
DOI:
Mots clés GATA3, plasmodium falciparum, hematopoietic malignancies.
Resume Background: Parasitic infectious diseases including malaria are the main causes of death among children in Africa. The susceptibility of children to infectious diseases could be due to molecular disorders that reduce the ability of immune system to fight properly parasites, bacteria or viruses. GATA-3 is a family member of the hematopoietic GATA transcription factors and is expressed by immune cells. GATA3 is a master regulator of lymphocyte T-helper 2 (Th2) cell differentiation in mature CD4+ T cells that mediate humoral immunity against extracellular pathogens including plasmodium falciparum (pf). The objective of the study is to investigate the expression of GATA3 in children admitted in hospital for fever and the relation with pf infection. Methods: Retrospective pilot study is done on 18 archived blood samples collected for red blood cells and pf counts in the laboratory of Zonal University hospital of Calavi/So-Ava (BENIN) prior to proper disease diagnosis among children (5-9 years) admitted for fever associated or not with malaria in 2011. Western blotting performed in the laboratory of UBBM was used to assess GATA3 expression. Results: Normal level of GATA3 was observed in 10/18 samples, low GATA3 was observed in 6/18 samples and total loss of GATA3 was observed on 2/18 samples. Infection with pf was observed on 7/18 samples with pf counts of 350-1500 per mm3 of red blood cells but absent in 11/18 samples. Conclusion: Although the deficiency of GATA3 does not correlate with pf counts, it might influence the ability of children to recover from pf infection. The absence of GATA3 may also expose them to the risk of developing lymphoma later in life.
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