Article, Ajoutée
le 17/01/2017 10:11
In a drug discovery program aimed at finding new anti-trypanosomal drugs, we developed the N, Ndimethylformamide.diiodine complex (DMF.I2) as an innovative and efficient green catalyst for the condensation reaction of aldehydes/ketones with arylthios [...]
KASSÉHIN URBAIN C. [1],
GBAGUIDI FERNAND A. [2],
MCCURDY CHRISTOPHER R. [3],
POUPAERT JACQUES H. [4],
Article, Ajoutée
le 17/01/2017 10:25
Relying on a straightforward « Green-Chemistry » based approach, this article reports an optimized Diels-Alder (DA) experimental set-up allowing for this reaction to be cleanly operated in the presence of water used both as solvent and catalyst. Thi [...]
GBAGUIDI A. FERNAND [1],
KASSÉHIN URBAIN C. [2],
PREVOST JULIEN R. C. [3],
FREDERICK RAPHAËL [4],
MCCURDY CHRISTOPHER R. [5],
POUPAERT JACQUES H. [6],
Article, Ajoutée
le 17/01/2017 10:32
Agomelatine, a melatonin-like antidepressant drug based on a naphthalene scaffold, has received considerable attention these last twenty years. This drug molecule undergoes important liver first pass effect and suffers therefore of a short plasma hal [...]
KASSÉHIN URBAIN C. [1],
GBAGUIDI A. FERNAND [2],
MCCURDY CHRISTOPHER R. [3],
POUPAERT JACQUES H. [4],
Article, Ajoutée
le 17/01/2017 10:48
Hydazones are molecules that inhibit the development of several microbes and parasites. They are known for their pharmacological activities: antimicrobial, antiviral, antitumor, antimalarial, Anticonvulsant. In this research, we synthesized with good [...]
ATCHADE BARDIEU [1],
KPOVIESSI DOSSOU SIKA SALOME [2],
GBAGUIDI A. FERNAND [3],
GLINMA BIENVENU [4],
AHOUSSI LÉON A. [5],
GBENOU JOACHIM [6],
ACCROMBESSI GEORGES C. [7],
FREDERICK RAPHAËL [8],
POUPAERT JACQUES H. [9],
Article, Ajoutée
le 17/01/2017 10:54
African trypanosomiasis remains a life-threatening disease and there is nowadays an urgent need for improved therapeutic agents for this pathology. In this context, in order to create novel anti-protozoa prototype containing both a trypanocidal thios [...]
KASSÉHIN URBAIN C. [1],
GBAGUIDI A. FERNAND [2],
MCCURDY CHRISTOPHER R. [3],
POUPAERT JACQUES H. [4],
Article, Ajoutée
le 17/01/2017 11:06
Hydrazones are nowadays considered to be good candidates for various pharmaceutical applications. Here, we have synthesized two series of hydrazones: salicylhydrazones (GS1-4) and p-tosylhydrazones (GT1-4) from S(+)-carvone and three aryketones with [...]
GLINMA BIENVENU [1],
GBAGUIDI A. FERNAND [2],
KASSÉHIN URBAIN C. [3],
KPOVIESSI DOSSOU SIKA SALOMÉ [4],
HOUNGBEME ALBAN [5],
HOUNGUE HORRHUS D. [6],
ACCROMBESSI GEORGES C. [7],
POUPAERT JACQUES H. [8],
Article, Ajoutée
le 17/01/2017 11:37
Trypanosomiasis constitutes a severe health problem for sub-saharian African and latin American population and there is an urgent need for better drugs to cure this life-threatening disease. In this context, aromatic thiosemicarbazones appears attrac [...]
KASSÉHIN URBAIN C. [1],
GBAGUIDI A. FERNAND [2],
MCCURDY CHRISTOPHER R. [3],
POUPAERT JACQUES H. [4],
Article, Ajoutée
le 17/01/2017 11:52
[...]
KASSÉHIN URBAIN C. [1],
GBAGUIDI A. FERNAND [2],
KAPANDA COCO N. [3],
MCCURDY CHRISTOPHER R. [4],
POUPAERT JACQUES H. [5],
Article, Ajoutée
le 17/01/2017 18:24
Montmorillonite K-10 was used in the acid catalysis of the Willgerodt-Kindler’s reaction (WK) under microwave heating for synthesis of thiobenzamides. Yields of 67% and 43% for the synthesis of morpholin-4yl (phenyl) methanethione (1) and [4 - (dimet [...]
AGNIMONHAN FINAGNON H. [1],
AHOUSSI AKANNI LÉON [2],
KPOVIESSI DOSSOU SIKA SALOMÉ [3],
GBAGUIDI A. FERNAND [4],
KAPANDA COCO N. [5],
MOUDACHIROU MANSOUROU [6],
POUPAERT JACQUES H. [7],
ACCROMBESSI GEORGES C. [8],
Article, Ajoutée
le 18/01/2017 08:44
This paper reports efforts aimed at tuning up the synthesis of a compound library centered on the general template 2amino-1-phenyl-2-thioxoethanonetakingthecondensationof [...]
KASSÉHIN URBAIN C. [1],
GBAGUIDI A. FERNAND [2],
KAPANDA COCO N. [3],
MCCURDY CHRISTOPHER R. [4],
POUPAERT JACQUES H. [5],