Human endogenous retroviruses (ERVs) represent 8% of the total human genome. Although the majority of these ancient proviral sequences have only retained non-coding long terminal repeats (LTRs), a number of "endogenized" retroviral genes encode funct [...]
LOKOSSOU ADJIMON GATIEN [1], TOUDIC CAROLINE [2], BARBEAU BENOIT [3],
BACKGROUND: The capacity of Plasmodium falciparum-infected erythrocytes to bind uninfected erythrocytes (rosetting) is associated with severe malaria in African children. Rosetting is mediated by a subset of the variant surface antigens PfEMP1 tar [...]
VIGAN-WOMAS INÈS [1], LOKOSSOU ADJIMON GATIEN [2], GUILLOTTE MICHELINE [3], JUILLERAT ALEXANDRE [4], BENTLEY GRAHAM [5], GARCIA ANDRÉ [6], MERCEREAU-PUIJALON ODILE [7], MIGOT-NABIAS FLORENCE [8],
Background Particular cytokine gene polymorphisms are involved in the regulation of the antibody production. The consequences of already described IL-4, IL-10 and IL-13 gene polymorphisms on biological parameters and antibody levels were investiga [...]
LOKOSSOU ADJIMON GATIEN [1], DECHAVANNE CÉLIA [2], BOURAÏMA AZIZ [3], COURTIN DAVID [4], LE PORT AGNÈS [5], LADEKPO RODOLPHE [6], NOUKPO JULIEN M [7], BONOU DÉSIRÉ [8], AHOUANGNINOU CLAUDE [9], SABBAGH AUDREY [10], FAYOMI BENJAMIN [11], MASSOUGBODJI ACHILLE [12], GARCIA ANDRÉ [12], MIGOT-NABIAS FLORENCE [12],
Human primary villous cytotrophoblasts are a very useful source of primary cells to study placental functions and regulatory mechanisms, and to comprehend diseases related to pregnancy. In this protocol, human primary villous cytotrophoblasts freshly [...]
LOKOSSOU ADJIMON GATIEN [1], TOUFAILY CHIRINE [2], VARGAS AMANDINE [3], BARBEAU BENOIT [4],
Syncytin-2 is encoded by the envelope gene of Endogenous Retrovirus-FRD (ERVFRD-1) and plays a critical role in fusion of placental trophoblasts leading to the formation of the multinucleated syncytiotrophoblast. Its expression is consequently regula [...]
LOKOSSOU ADJIMON GATIEN [1], TOUFAILY CHIRINE [1], VARGAS AMANDINE [3], RASSART ÉRIC [4], BARBEAU BENOIT [5],
Background Transplacental transfer of maternal immunoglobulin G (IgG) to the fetus helps to protect against malaria and other infections in infancy. Recent studies have emphasized the important role of malaria-specific IgG3 in malaria immunity, an [...]
DECHAVANNE CÉLIA [1], DECHAVANNE SÉBASTIEN [2], SADISSOU IBRAHIM [3], LOKOSSOU ADJIMON GATIEN [4], ALVARADO FERNANDA [5], DAMBRUN MAGALIE [6], MOUTAIROU KABIROU [7], COURTIN DAVID [8], NUEL GREGORY [9], GARCIA ANDRÉ [10], MIGOT-NABIAS FLORENCE [11], KING L CHRISTOPHER [12],
Syncytin-1 and Syncytin-2 are two human endogenous retroviral glycoproteins that are expressed in the human placenta. In this tissue, both proteins play important roles in the development of a healthy and functional placenta. Indeed, the conserved fu [...]
TOUDIC CAROLINE [1], ELISSEEFF XAVIER [2], LOKOSSOU ADJIMON GATIEN [3], BARBEAU BENOIT [4],