Human endogenous retroviruses (ERVs) represent 8% of the total human genome. Although the majority of these ancient proviral sequences have only retained non-coding long terminal repeats (LTRs), a number of "endogenized" retroviral genes encode funct [...]
LOKOSSOU ADJIMON GATIEN [1], TOUDIC CAROLINE [2], BARBEAU BENOIT [3],
Human primary villous cytotrophoblasts are a very useful source of primary cells to study placental functions and regulatory mechanisms, and to comprehend diseases related to pregnancy. In this protocol, human primary villous cytotrophoblasts freshly [...]
LOKOSSOU ADJIMON GATIEN [1], TOUFAILY CHIRINE [2], VARGAS AMANDINE [3], BARBEAU BENOIT [4],
Syncytin-2 is encoded by the envelope gene of Endogenous Retrovirus-FRD (ERVFRD-1) and plays a critical role in fusion of placental trophoblasts leading to the formation of the multinucleated syncytiotrophoblast. Its expression is consequently regula [...]
LOKOSSOU ADJIMON GATIEN [1], TOUFAILY CHIRINE [1], VARGAS AMANDINE [3], RASSART ÉRIC [4], BARBEAU BENOIT [5],
Syncytin-1 and Syncytin-2 are two human endogenous retroviral glycoproteins that are expressed in the human placenta. In this tissue, both proteins play important roles in the development of a healthy and functional placenta. Indeed, the conserved fu [...]
TOUDIC CAROLINE [1], ELISSEEFF XAVIER [2], LOKOSSOU ADJIMON GATIEN [3], BARBEAU BENOIT [4],