Human endogenous retroviruses (ERVs) represent 8% of the total human genome. Although the majority of these ancient proviral sequences have only retained non-coding long terminal repeats (LTRs), a number of "endogenized" retroviral genes encode funct [...]
LOKOSSOU ADJIMON GATIEN [1], TOUDIC CAROLINE [2], BARBEAU BENOIT [3],
Human primary villous cytotrophoblasts are a very useful source of primary cells to study placental functions and regulatory mechanisms, and to comprehend diseases related to pregnancy. In this protocol, human primary villous cytotrophoblasts freshly [...]
LOKOSSOU ADJIMON GATIEN [1], TOUFAILY CHIRINE [2], VARGAS AMANDINE [3], BARBEAU BENOIT [4],
Syncytin-2 is encoded by the envelope gene of Endogenous Retrovirus-FRD (ERVFRD-1) and plays a critical role in fusion of placental trophoblasts leading to the formation of the multinucleated syncytiotrophoblast. Its expression is consequently regula [...]
LOKOSSOU ADJIMON GATIEN [1], TOUFAILY CHIRINE [1], VARGAS AMANDINE [3], RASSART ÉRIC [4], BARBEAU BENOIT [5],
Syncytin-2 is an envelope protein that plays a key role in placental formation through the fusion of villous cytotrophoblasts (CTV), which leads to the formation of the syncytiotrophoblast (ST). The syncytiotrophoblast plays a key role in the functio [...]
LOKOSSOU GATIEN [1], DAVITO LUCIEN [2], BADAROU AMYRATH [3], ACCROMBESSI MANFRED [4], AZONNAKPO JULIEN [5], KOUNOUDJI GISCARDE [6], LOSEZ EVELYNE JOSETTE MARIE [6], HOUNKPATIN BENJAMIN IGNACE B. [6], PERRIN RENÉ-XAVIER [6], BABA MOUSSA LAMINE [6], BARBEAU BENOIT [6],
Preeclampsia represents a danger to nearly 10 million pregnant women worldwide. This gestational pathology has very important consequences for preeclamptic (PE) women but also for newborns. To date, no early diagnostic tools are ava [...]
LOKOSSOU GATIEN [1], TOUDIC CAROLINE [2], LOZES EVELYNE JOSETTE MARIE [3], DAVITO LUCIEN [4], BADAROU AMYRATH [5], PERRIN RENÉ-XAVIER [6], BARBEAU BENOIT [6],
3AbstractModulation of the activation status of immune cell populations during pregnancydepends on placental villous cytotrophoblast (VCT)cellsand the syncytiotrophoblast (STB) layer. Failure in the establishment of this immunoregulatory [...]
LOKOSSOU GATIEN [1], TOUDIC CAROLINE [2], NGUYEN PHUONG TRANG [3], XAVIER ELISSEEFF [4], VARGAS AMANDINE [5], RASSART ÉRIC [6], LAFOND JULIE [6], LEDUC LINE [6], BOURGAULT STEVE [6], GILBERT CAROLINE [6], SCORZA TATIANA [6], TOLOSA JORGE [6], BARBEAU BENOIT [6],
Preeclampsia (PE) affects 2 to 8% of pregnant women and represents one of the major causes of maternal and perinatal morbidity and mortality, particularly in sub-Saharan Africa. A limited number of biomarkers have been proposed for the identification [...]
LOKOSSOU GATIEN [1], DAVITO LUCIEN [2], BADAROU AMYRATH [3], ACCROMBESSI MANFRED [4], AZONNAKPO JULIEN [5], KOUNOUDJI GISCARDE [6], LOSEZ EVELYNE JOSETTE MARIE [6], OSSOU-GBÉTÉ LUCIEN [6], HOUNKPATIN BENJAMIN IGNACE B. [6], PERRIN RENÉ-XAVIER [6], BARBEAU BENOIT [6],
Syncytin-1 and Syncytin-2 are two human endogenous retroviral glycoproteins that are expressed in the human placenta. In this tissue, both proteins play important roles in the development of a healthy and functional placenta. Indeed, the conserved fu [...]
TOUDIC CAROLINE [1], ELISSEEFF XAVIER [2], LOKOSSOU ADJIMON GATIEN [3], BARBEAU BENOIT [4],