Kasséhin Urbain C. [1], Gbaguidi Fernand A. [2], McCurdy Christopher R. [3], Poupaert Jacques H. [4],
In a drug discovery program aimed at finding new anti-trypanosomal drugs, we developed the N, Ndimethylformamide.diiodine complex (DMF.I2) as an innov [...]
Article, Ajoutée le 17/01/2017 10:11
Gbaguidi A. Fernand [1], Kasséhin Urbain C. [2], Prevost Julien R. C. [3], Frederick Raphaël [4], McCurdy Christopher R. [5], Poupaert Jacques H. [6],
Relying on a straightforward « Green-Chemistry » based approach, this article reports an optimized Diels-Alder (DA) experimental set-up allowing for t [...]
Article, Ajoutée le 17/01/2017 10:25
Kasséhin Urbain C. [1], Gbaguidi A. Fernand [2], McCurdy Christopher R. [3], Poupaert Jacques H. [4],
Agomelatine, a melatonin-like antidepressant drug based on a naphthalene scaffold, has received considerable attention these last twenty years. This d [...]
Article, Ajoutée le 17/01/2017 10:32
Kasséhin Urbain C. [1], Gbaguidi A. Fernand [2], McCurdy Christopher R. [3], Poupaert Jacques H. [4],
African trypanosomiasis remains a life-threatening disease and there is nowadays an urgent need for improved therapeutic agents for this pathology. In [...]
Article, Ajoutée le 17/01/2017 10:54
Kasséhin Urbain C. [1], Gbaguidi A. Fernand [2], McCurdy Christopher R. [3], Poupaert Jacques H. [4],
Trypanosomiasis constitutes a severe health problem for sub-saharian African and latin American population and there is an urgent need for better drug [...]
Article, Ajoutée le 17/01/2017 11:37
Kasséhin Urbain C. [1], Gbaguidi A. Fernand [2], Kapanda Coco N. [3], McCurdy Christopher R. [4], Poupaert Jacques H. [5],
Article, Ajoutée le 17/01/2017 11:52
Kasséhin Urbain C. [1], Gbaguidi A. Fernand [2], Carato Pascal [3], McCurdy Christopher R. [4], Poupaert Jacques H. [5],
Based on a rational approach using merely bioisosterism as euristic tool, we designed and tested a short series of congeners of 6-benzoyl-2(3H)-benzox [...]
Article, Ajoutée le 18/01/2017 09:01
Kasséhin Urbain C. [1], Gbaguidi A. Fernand [2], Kapanda Coco N. [3], McCurdy Christopher R. [4], Bigot André K. [5], Poupaert Jacques H. [6],
A concise series of aldehydes and ketones were reacted in a condensation reaction with 4phenylthiosemicarbazide in order to assess the relative influe [...]
Article, Ajoutée le 18/01/2017 10:44
Poupaert Jacques H. [1], Gbaguidi A. Fernand [2], Kapanda Coco N. [3], Aichaoui Hocine [4], McCurdy Christopher R. [5],
Based on a line of evidence (logP, pKa, 1H-, and 13C-NMR, and molecular modeling studies), it appears that cocaine undergoes a hydrophobic collapse wh [...]
Article, Ajoutée le 19/01/2017 10:29
Kasséhin Urbain C. [1], Gbaguidi A. Fernand [2], Carato Pascal [3], McCurdy Christopher R. [4], Accrombessi Georges C. [5], Poupaert Jacques H. [6],
A green synthesis of tetracyclone (2, 3, 4, 5-tetraphenyl-2, 4-cyclopentadien-1-one) has been conceived and executed on the basis of a rationale desig [...]
Article, Ajoutée le 25/01/2017 08:29