Les maladies infectieuses sont à l’origine d’un taux élevé de mortalité de par le monde, en particulier dans les pays en voie de développement. Cette situation est aggravée par les phénomènes d’antibiorésistance consécutives à une utilisation non rat [...]
The quality control of medicines is one of the key factors which determine its efficacy. In Africa, particularly in Benin, a large population often uses traditional medicines. Therefore, controlling their quality becomes a major concern for public he [...]
Over the past century, research on cancer has increased due to the importance of the disease as sixth leading cause of mortality worldwide. Several medicines, methods and strategies have been used to cure the disease. However, the problematic of drug [...]
Small size and high polar basic compounds have always been challenging with heavy matrix effect due to their difficult complete separation from polar endogenous compounds contained in most biological matrix. In this study, a relevant design including [...]
The effect of a Traditional Chinese herbal formulation, K-601, on the pharmacokinetics of paracetamol (acetaminophen) was investigated. A simple high performance liquid chromatography-single quadrupole mass spectrometric (LC/MS) analytical method was [...]
Discovered in 1965, liposome an artificial vesicle that is composed of one or more concentric phospholipid bilayers and is used especially to deliver microscopic substances (as DNA or drugs) to body cells. Liposomes have been investigated for improvi [...]
Objective To evaluate the scientific basis for the use of Kang 601 heji (K-601) as an anti-inflammatory and antipyretic agent using appropriate animal models. Methods Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to [...]
Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor [...]
This paper highlights the availability, pricing and affordability of popular medicines in Comoros. We used the standardized survey methodology developed by the World Health Organization and Health Action International to conduct a cross sectional sur [...]
Multidrug resistance (MDR) remains the primary issue in cancer therapy, which is characterized by the overexpressed P-glycoprotein (P-gp)-included efflux pump or the upregulated anti-apoptotic proteins. In this study, a D-alpha-tocopheryl poly (ethyl [...]