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[ Article ] Antimicrobial resistance in hospitalized surgical patients: a silently emerging public health concern in Benin
| Date de soumission: | 18-02-2021 |
|---|---|
| Année de Publication: | 2020 |
| Entité/Laboratoire | Laboratoire de Bacteriologie-Virologie (LBV) |
| Document type : | Article |
| Discipline(s) : | Médecine de Laboratoire & Technologie Médicale |
| Titre | Antimicrobial resistance in hospitalized surgical patients: a silently emerging public health concern in Benin |
|---|---|
| Auteurs | AFFOLABI DISSOU [3], |
| Journal: | Ann Clin Microbiol Antimicrob |
| Catégorie Journal: | Internationale |
| Impact factor: | 2.7 |
| Volume Journal: | 19 |
| DOI: | 10.1186/s12941-020-00398-4 |
| Resume | Abstract Background: Surgical site infections are related to high morbidity, mortality and healthcare costs. Because the emergence of multidrug-resistant bacteria in hospitals is becoming a worldwide challenge for surgeons who treat healthcare-associated infections, we wished to identify the causative agents involved in these infections and the rate of multidrug-resistant bacteria in six public hospitals in Benin. Methods: Using standard microbiological procedures, we processed pus specimens collected from obstetrics and gastrointestinal surgery wards. Mass spectrometry (MALDI-TOF) was used for confirmation. For the antibiotic susceptibility test, we first used the Kirby-Bauer disk diffusion method. The secondary test (by microdilution) used the Beckton Dickinson Phoenix automated system (Becton Dickinson Diagnostic, USA). Results: We included 304 patients, whose median length of stay was 9 days. A total of 259 wound swabs (85.2%) had positive aerobic bacterial growth. In obstetrics, S. aureus (28.5%, n = 42) was the most common isolate. In contrast, Gram-negative bacteria (GNB) were predominant in gastrointestinal surgery, the most dominant being E.coli (38.4%, n = 31). Overall, 90.8% (n = 208) of aerobic bacteria were multidrug resistant. Two-thirds of S. aureus (65.3%, n = 32) were methicillin-resistant Staphylococcus aureus (MRSA), three of which carried both MRSA and induced clindamycin resistance (ICR). GNB showed high resistance to ceftazidime, ceftriaxone and cefepime. Extended-spectrum beta-lactamases were presented by 69.4% of E.coli (n = 43/62) and 83.3% of K. pneumoniae (n = 25/30). Overall, twelve Gramnegative bacteria (5.24%) showed resistance to at least one carbapenem. No isolates showed a wild-type susceptible phenotype. Conclusion: This study shows the alarming prevalence of multidrug-resistant organisms from surgical site infections in Benin hospitals. To reduce the spread of such bacteria in Benin, periodic surveillance of surgical site infections and strict adherence to good hand-hygiene practice are essential. |
| Mots clés | ESBL, Methicillin-resistant staphylococcus aureus, Surgical site infection, Multidrug-resistant organisms |
| Pages | 1 - 10 |
| Fichier |  (PDF) |
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