Publications Scientifiques

[ Article ] In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria

Date de soumission:	31-01-2017
Année de Publication:	2009
Entité/Laboratoire	Laboratoires de Chimie Organique Phisyque et de Synthèse (LRCOPS)
Document type :	Article
Discipline(s) :	Chimie

Titre	In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria
Auteurs	Bero Joanne [1], Ganfon Habib [2], Jonville Marie-Caroline [3], FREDERICH Michel [4], Gbaguidi A. Fernand [5], DeMol Patrick [6], MOUDACHIROU MANSOUROU [7], Quetin-Leclercq Joëlle [8],
Journal:	Journal of Ethnopharmacology
Catégorie Journal:	Internationale
Impact factor:	3.055
Volume Journal:	122
DOI:
Resume	Aim of the study: The aim of the study was to evaluate the in vitro antiplasmodial activity of crude extracts of 12 plant species traditionally used in Benin for the treatment of malaria in order to validate their use. Materials and methods: For each species, dichloromethane, methanol and total aqueous extracts were tested. The antiplasmodial activity of extracts was evaluated using the measurement of the plasmodial lactate dehydrogenase activity on chloroquine-sensitive (3D7) and resistant (W2) strains of Plasmodium falciparum. The selectivity of the different extracts was evaluated using the MTT test on J774 macrophagelike murine cells and WI38 human normal fibroblasts. Results: The best growth inhibition of both strains of Plasmodium falciparum was observed with the dichloromethane extracts of Acanthospermum hispidum DC. (Asteraceae) (IC50 = 7.5 g/ml on 3D7 and 4.8 g/ml on W2), Keetia leucantha (K. Krause) Bridson (syn. Plectronia leucantha Krause) (Rubiaceae) leaves and twigs (IC50 = 13.8 and 11.3 g/ml on 3D7 and IC50 = 26.5 and 15.8 g/ml on W2, respectively), Carpolobia lutea G.Don. (Polygalaceae) (IC50 = 19.4 g/ml on 3D7 and 8.1 g/ml on W2) and Strychnos spinosa Lam. (Loganiaceae) leaves (IC50 = 15.6 g/ml on 3D7 and 8.9 g/ml on W2). All these extracts had a low cytotoxicity. Conclusion: Our study gives some justifications for the traditional uses of some investigated plants.
Mots clés	Antiplasmodial activity Traditional medicine Benin Acanthospermum hispidum Keetia leucantha Carpolobia lutea Strychnos spinosa
Pages	439 - 444
Fichier	(PDF)

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