Publications Scientifiques

[ Article ] Volatile oil composition and antiproliferative activity of Hyptis spicigera Lam against human breast adenocarcinoma cells MCF-7

Date de soumission: 03-02-2017
Année de Publication: 2013
Entité/Laboratoire Laboratoire d'Etude et de Recherche en Chimie Appliquée (LERCA)
Document type : Article
Discipline(s) : Chimie
Titre Volatile oil composition and antiproliferative activity of Hyptis spicigera Lam against human breast adenocarcinoma cells MCF-7
Auteurs Bogninou-Agbidinoukou G. Sophie [1], YEDOMONHAN HOUNNANKPON [2], AVLESSI FÉLICIEN [3], SOHOUNHLOUE KOKO CODJO DOMINIQUE [4], Chalard Pierre [5], CHALCHAT Jean C. [6],
Journal: Research Journal of Chemical Sciences
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 2
DOI:
Resume This study reported the chemical composition and the evaluation of the in vitro antiproliferative activity of volatile extracts of Hyptis spicigera (HS) on breast cancer cells MCF-7. Essential oils (EO) HS1 and HS2 extracted from leafy stems of H. spicigera by hydrodistillation after different harvesting periods were characterized by gas chromatography/flame ionization detector (GC/FID) and gas chromatography/mass spectrometry (GC/MS). The cytotoxicity of these volatile extracts was tested in order to assess their antiproliferative activity on cancer cells MCF-7 by the resazurin test. Chromatographic analysis revealed several major compounds depending on the harvest period of vegetable. Sample HS1 was characterized by -pinene (16.9%), sabinene (13.8%), -pinene (9.6%) and 1,8-cineole (9.6%), while HS2 was potentially rich in - caryophyllene (53.2%), caryophyllene oxide (5.4%) and -humulene (3.8%). Biological investigations performed have shown that HS1 and HS2 were cytotoxic against MCF-7 cells. Inhibitory concentrations values (IC50) determined for this purpose were 170 and 84 μg/mL respectively for HS1 and HS2. Major compounds of the EO should be responsible for this inhibitory activity.
Mots clés Hyptis spicigera, volatile extract, MCF-7, -caryophyllene, -pinene, Benin.
Pages 27 - 31
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