Publications Scientifiques

[ Article ] Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin

Date de soumission: 09-02-2017
Année de Publication: 2013
Entité/Laboratoire Laboratoire de Recherche en Biologie Appliquée (LARBA)
Document type : Article
Discipline(s) : Microbiologie
Titre Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin
Auteurs DOUGNON T. VICTORIEN [1], BANKOLE HONORÉ SOUROU [1], KLOTOE J.R. [1], SENOU MAXIMIN [1], AKPOVI DEWANOU CASIMIR [1], LOKO CHRISTIAN FRÉDÉRIC SIMPLICE [1], BOKO MICHEL [1], DOUGNON TOSSOU JACQUES [1],
Journal: Avicenna Journal of Phytomedicine
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 4
DOI:
Resume Objective: Hypercholesterolemia is the greatest risk factor for cardiovascular diseases. The present study is conducted to evaluate the lipid lowering activity of leaves and fruits of Solanum macrocarpon, a vegetable, on Wistar rats experimentally rendered hypercholesterolemic by Triton X-100. Materials and Methods: The leaves and fruits were administered (p.o.) for 7 days to rats at doses of 400 and 800 mg/kg of body weight. Atorvastatin was used as reference treatment drug. The data were analyzed by the Brown-Forsythe ANOVA, Dunnett’s T3 multiple comparison test, and Dunnett’s t test. All tests were done at the 5% significance level. Results: Administration of S. macrocarpon (fruits as well as leaves) resulted in a statistically significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol, and triglycerides in the treated groups compared with the untreated hypercholesterolemic group, regardless of the administrated doses. A significant increase in HDL-cholesterol was observed in the treated groups. Hepatic disorders due to the Triton have been corrected by S. macrocarpon. Conclusions: This vegetable effectively suppresses experimental hypercholesterolemia in Wistar rats, suggesting a protective role in cardiovascular diseases. Its use by individuals at risk should be promoted.
Mots clés Cholesterolemia Feeding Regulation Solanum macrocarpon Wistar rats
Pages 160 - 169
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