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[ Article ] Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity

Date de soumission: 24-02-2017
Année de Publication: 2015
Entité/Laboratoire Laboratoire de Biologie et de Physiologie Cellulaires (LBPC)
Document type : Article
Discipline(s) : Biochimie, biophysique & Biologie Moléculaire
Titre Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity
Auteurs YESSOUFOU AKADIRI [1], NEKOUA Magloire Pandoua [2], GBANKOTO Adam [3], MASHALLA YOHANA [4], MOUTAIROU KABIROU [5],
Journal: Journal of Diabetes Research
Catégorie Journal: Internationale
Impact factor: 2.431
Volume Journal: 2015
DOI: doi: 10.1155/2015/731434.
Resume Omega-3 polyunsaturated fatty acids (PUFAs) are increasingly being used to prevent cardiovascular diseases, including diabetes and obesity. In this paper, we report data on the observed effects of omega-3 PUFA on major metabolic disorders and immune system disruption during gestational diabetes and their consequences on macrosomia.While controversies still exist about omega- 3 PUFA effects on antioxidant status regarding the level of omega-3 PUFA in diet supplementation, their lipid-lowering effects are unanimously recognized by researchers. Animal studies have shown that omega-3 PUFA contributes to the maintenance of the immune defense system by promoting the differentiation of T helper (Th) cell to a Th2 phenotype in diabetic pregnancy and by shifting the Th1/Th2 ratio from a deleterious proinflammatory Th1 phenotype to a protective anti-inflammatory Th2 phenotype in macrosomia and in adulthood obesity that results from macrosomia at birth. Based on the available evidence, international nutritional and food agencies recommend administration of omega-3 PUFA as triglyceride-lowering agents, for the prevention of cardiovascular disease risk and during human pregnancy and lactation. Furthermore, studies targeting humans are still required to explore application of the fatty acids as supplement in the management of gestational diabetes and inflammatory and immune diseases.
Mots clés Omega-3 PUFA; gestational diabetes; macrosomia; Immune system; Antioxidant status; Lipid metabolism.
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