Publications Scientifiques

[ Article ] Toxicology of deoxynivalenol and its acetylated and modified forms

Date de soumission: 07-03-2017
Année de Publication: 2016
Entité/Laboratoire Autres laboratoires
Document type : Article
Discipline(s) : Pharmacie, Pharmacologie & Toxicologie
Titre Toxicology of deoxynivalenol and its acetylated and modified forms
Journal: Archives of Toxicology
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 90
DOI: 10.1007/s00204-016-1826-4
Resume Mycotoxins are the most frequently occurring natural contaminants in human and animal diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most prevalent and thus represents an important health risk. Recent detection methods revealed new mycotoxins and new molecules derivated from the “native” mycotoxins. The main derivates of DON are the acetylated forms produced by the fungi (3- and 15-acetyl-DON), the biologically “modified” forms produced by the plant (deoxynivalenol-3-β-d-glucopyranoside), or after bacteria transformation (de-epoxy DON, 3-epi-DON and 3-keto-DON) as well as the chemically “modified” forms (norDON A-C and DON-sulfonates). High proportions of acetylated and modified forms of DON co-occur with DON, increasing the exposure and the health risk. DON and its acetylated and modified forms are rapidly absorbed following ingestion. At the molecular level, DON binds to the ribosome, induces a ribotoxic stress leading to the activation of MAP kinases, cellular cell-cycle arrest and apoptosis. The toxic effects of DON include emesis and anorexia, alteration of intestinal and immune functions, reduced absorption of the nutrients as well as increased susceptibility to infection and chronic diseases. In contrast to DON, very little information exists concerning the acetylated and modified forms; some can be converted back to DON, their ability to bind to the ribosome and to induce cellular effects varies according to the toxin. Except for the acetylated forms, their toxicity and impact on human and animal health are poorly documented.
Mots clés Deoxynivalenol, Acetylated forms, Modified forms,Toxicokinetics, Ribosome binding, Toxicity, Health effects
Pages 2931 - 2957
Fichier (PDF)

Publications par entité

  • Centre de Formation et de Recherche en matière de Population (CEFORP) (15)
  • Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable (CIFRED) (18)
  • Chaire Internationale en Physique Mathématique et Applications (CIPMA-Chaire UNESCO) (16)
  • Ecole Doctorale Pluridisciplinaire <<Espaces, Culture et Développement>> (0)
  • Ecole Nationale d'Administration et de Magistrature (ENAM) (47)
  • Ecole Nationle d'Economie Appliquée et de Management (80)
  • Ecole Normale Supérieure (24)
  • Ecole Polytechnique d'Abomey-Calavi (EPAC) (877)
  • Faculté de droit et de Science Politique (FADESP) (57)
  • Faculté des Lettres et Sciences Humaines (FLASH) (889)
  • Faculté des Lettres, Langues, Arts et Communications (FLLAC) (0)
  • Faculté des Sciences Agronomiques (1433)
  • Faculté des Sciences de la Santé (FSS) (1757)
  • Faculté des Sciences Economiques et de Gestion (FASEG) (144)
  • Faculté des Sciences et Techniques (FAST) (789)
  • Faculté des Sciences Humaines et Sociales (FASHS) (19)
  • Institut de Formation et de Recherche en Informatique (IFRI) (72)
  • Institut de Mathématiques et de Sciences Physiques (IMSP) (75)
  • Institut National de l'Eau (INE) (13)
  • Institut National des Métiers d'Art d'Archéologie et de la Culture (INMAAC) (4)
  • Institut National Médico Sanitaire ( INMeS) (0)
  • Institut Régional de Santé Publique (IRSP) (51)

Publications par sexe

  • Femme( 993 )
  • Homme (