Publications Scientifiques

[ Article ] Moringa oleifera-Rich Diet and T-Cell Calcium Signaling in Hypertensive Rats.

Date de soumission: 15-02-2018
Année de Publication: 2017
Entité/Laboratoire Laboratoire de Physiopathologie Moléculaire et Toxicologie (LPMT)
Document type : Article
Discipline(s) : Pharmacie, Pharmacologie & Toxicologie
Titre Moringa oleifera-Rich Diet and T-Cell Calcium Signaling in Hypertensive Rats.
Auteurs Attakpa Sèlidji Eugène [1], Gbaguidi Bertin A. [2], Chabi Nicodème W. [3], Ategbo Jean-Marc [4], Seri Bialli [5], Khan Naim Akhtar [6],
Journal: Physiological Research
Catégorie Journal: Internationale
Impact factor: 1.644
Volume Journal: 66
DOI:
Resume Moringa oleifera (M.O) is a plant whose fruits, roots and leaves have been advocated for traditional medicinal uses. The physico-chemical analysis shows that, Moringa contains more dietary polyunsaturated fatty acids (PUFA) than saturated fatty acids (SFA). The consumption of an experimental diet enriched with Moringa oleifera extracts lowered blood pressure in spontaneously hypertensive rats (SHR), but not in normotensive Wistar-Kyoto (WKY) rats as compared to rats fed an unsupplemented control diet. Anti-CD3-stimulated T-cell proliferation was diminished in both strains of rats fed the Moringa oleifera. The experimental diet lowered secretion of interleukin-2 in SHR, but not in WKY rats compared with rats fed the control diet. Studies of platelets from patients with primary hypertension and from SHR support the notion that the concentration of intracellular free calcium [Ca2+]i is modified in both clinical and experimental hypertension. We observed that the basal, [Ca2+]i was lower in T cells of SHR than in those of WKY rats fed the control diet. Feeding the diet with Moringa oleifera extracts to WKY rats did not alter basal [Ca2+]i in T cells but increased basal [Ca2+]i in SHR. Our study clearly demonstrated that Moringa oleifera exerts antihypertensive effects by inhibiting the secretion of IL-2 and modulates T-cell calcium signaling in hypertensive rats.
Mots clés Moringa oleifera, genetic hypertension, intracellular calcium, immunomodulation, T cells, rats
Pages 753 - 767
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