||Background: The implementation of the antimicrobial therapy greatly improved Buruli Ulcer (BU)
care. Nevertheless, the disease still imposes significant burden. In rural endemic areas, many
patients are being healed from the disease with disabling sequels. They are living without social
assistance in a context of poverty. Various researches have evaluated the therapeutic modalities
that are used to control the BU disease, but any study on the quality of life (QOL) of the patients
healed from BU has been reported.
Methodology/Principal Findings: A total of 105 patients healed from Buruli ulcer and, 105 control subjects without Buruli ulcer history are enrolled in the study after giving well-informed consent.
The Medical Outcome Study Short Form (SF-36) is administrated to access their QOL. The study
is approved by the Ethical committee of the Faculty of Health Sciences of the University of
Abomey-Calavi (UAC). All the patients have a weak QOL than control subjects. The deterioration
affects their physical functioning, their physical role, their emotional role and their mental health
(p<0.05). However, in spite of their low QOL, subjects aged from 40 years old and over (p = 0.003),
and subjects married, divorced or widowed (p = 0.01) work physically better than the other subgroups,
even if they are mentally weaker. In a Spearman correlation test, we have observed
significant relationships of socio-economic variable with the decrease of SF-36 subscale values.
Conclusion/Significance: BU patients are healed in a long-term physically and psychologically
marked by the sequels induced by the disease. The results of the present study suggest that
interventions and supports are needed to improve the QOL of these patients.