Publications Scientifiques

[ Article ] Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin

Date de soumission: 12-06-2017
Année de Publication: 2015
Entité/Laboratoire Laboratoire de Recherche en Biologie Appliquée (LARBA)
Document type : Article
Discipline(s) : Biochimie, biophysique & Biologie Moléculaire
Titre Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin
Auteurs AKPOVI DEWANOU CASIMIR [1], SEGBO JULIEN A. GAÉTAN [2], MEDEHOUENOU THIERRY COMLAN MARC [3], ANAGO AHOÉFA AMÉLÉ EUGÉNIE [4],
Journal: International Journal of Biomedical Research
Catégorie Journal: Internationale
Impact factor: 0.0743
Volume Journal: 6
DOI: 10.7439/ijbr
Resume Background: Abnormal lipid profile is common in subjects with type 2 diabetes (T2D). Despite use of lipid- lowering agents, many subjects with T2D do not achieve lipid targets. The present work aimed to assess lipid profile in a randomly selected group of adult diabet ic subjects under treatment in order to determine how diabetes treatment affects blood lipid parameters levels. HbA1c level is used as a biomarker of glycaemia control achievement and treatment success in diabetic. Methods: This study was carried out as a pre-post test design study with a control group. A total of 117 diabetic subjects under treatment and 100 non-diabetics as control subjects are included in the study. TC, TG and HDL- C were measured by enzymatic methods and LDL-C was determined by Friedewald formula. Plasma glucose was measured by Glucose Oxidase method and glycated hemoglobin (HbA1c) with a radioimmunoassay. Results: The results showed that TC (p<0.001), LDLc (p<0.001) and TG (p=0.02) levels increased significantly in diabetics compared to controls. Atherogenic indices TC/HDL-C (p<0.01) and LDL-C/HDL-C (p<0.01), and blood calcium level (p<0.001) were significantly increased in diabetics than in controls. Subjects with HbA1c value >7.0% had significantly higher levels of TC (P<0.01), LDL-C (p<0.05), TC/HDL-C (p<0.01), LDL- C/HDL-C (p=0.02), TG/HDL-C (p=0.01) and calcemia (p<0.001) compared to subjects with HbA1c ≤7.0%. Conclusion: Significant difference of lipid parameters was observed in diabetics with HbA1c ≤7.0% and >7.0%. Abnormal lipid patterns and insulin resistance tend to be normalized with therapy of diabetes.
Mots clés Type 2 diabetes, HbA1c, lipid parameter, insulin resistance, Benin
Pages 805 - 810
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