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[ Livre ] Gerd Pluschke. Mycobacterium ulcerans Disease. Manson's Tropical Infectious Diseases

Date de soumission: 23-06-2017
Année de Publication: 2014
Document type : Livre
Discipline(s) :
Titre Gerd Pluschke. Mycobacterium ulcerans Disease. Manson's Tropical Infectious Diseases
Auteurs Junghanss Thomas [1], JOHNSON ROCH CHRISTIAN [2],
ISBN: 9780702051012
Resume ycobacterium ulcerans disease (‘Buruli ulcer’, BU) is the most common mycobacterial disease in humans after tuberculosis (see Chapter 40) and leprosy (see Chapter 41). • M. ulcerans disease mainly affects children, and is stigmatizing, disfiguring and disabling if not treated early. • Sub-Saharan Africa carries the main burden of disease, but it also occurs in Asia, the South Pacific and Latin America. • Active early case detection and treatment are key to improving outcome. • M. ulcerans disease can be treated effectively with antibiotics, particularly when treated early. • The potential development of drug resistance needs to be carefully observed. • In addition to specific treatment, patients require wound care and, in advanced disease, skin grafting. • Patients with advanced disease in particular require nutritional and psychological support, physiotherapy and reconstructive surgery. • Sooner or later after the initiation of antimycobacterial treatment, healing frequently stops or deteriorates for some time (so-called ‘paradoxical reaction’). A major challenge is to distinguish this from secondary bacterial infections and specific treatment failure (which is rare). • Prevention is limited since the modes of transmission which could be targeted are still unclear.
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