| Titre |
Combined effects of Gm or Km immunoglobulin allotypes and age on antibody responses to Plasmodium falciparum VarO rosetting variant in Benin. |
| Auteurs |
Migot-Nabias Florence [1],
Lokossou Adjimon G. Gatien [2],
Vigan-Womas Inès [3],
Guitard Evelyne [4],
Guillotte Micheline [5],
Noukpo Julien M [6],
Mercereau-Puijalon Odile [7],
Dugougon Jean-Michel [8],
Garcia André [9],
|
| Journal: |
Microbes and Infections |
| Catégorie Journal: |
Internationale |
| Impact factor: |
2.152 |
| Volume Journal: |
13 |
| DOI: |
10.1016/j.micinf.2011.04.001 |
| Resume |
Clinical protection of Beninese children against Plasmodium falciparum malaria was shown to be influenced by immunoglobulin (IG) Gm and Km allotypes, and related to seroreactivity with the rosette-forming VarO-antigenic variant. IgG to the VarO-infected erythrocyte surface, IgG1 and IgG3 to PfEMP1-NTS-DBL1α(1)-VarO were higher in the under 4-year-old children carrying the Gm 5,6,13,14;1,17 phenotype. In contrast, surface-reactive IgG, total IgG, IgG1 and IgG3 to NTS-DBL1α(1)- and DBL2βC2-VarO domains were lower in the above 4-year-old children harbouring the Km1 allotype. These data outline an age-related association of antibodies against malaria antigens and IG allotype distribution. |
| Mots clés |
Allotypes, Immunoglobulin, Plasmodium falciparum |
| Pages |
771 - 775 |
| Fichier |
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