Publications Scientifiques

[ Livre ] Roles of Endogenous Retrovirus-Encoded Syncytins in Human Placentation

Date de soumission: 07-02-2018
Année de Publication: 2017
Entité/Laboratoire Laboratoire de Recherche en Biologie Appliquée (LARBA)
Document type : Livre
Discipline(s) : Immulogie & maladie infectueuse
Titre Roles of Endogenous Retrovirus-Encoded Syncytins in Human Placentation
Auteurs Toudic Caroline [1], Elisseeff Xavier [2], Lokossou Adjimon Gatien [3], Barbeau Benoit [4],
Editeur:
Edition: Springer, Cham
ISBN: 978-3-319-48343-6
DOI: https://doi.org/10.1007/978-3-319-48344-3_9
Resume Syncytin-1 and Syncytin-2 are two human endogenous retroviral glycoproteins that are expressed in the human placenta. In this tissue, both proteins play important roles in the development of a healthy and functional placenta. Indeed, the conserved fusogenic properties that characterize Syncytin proteins among the mammalian clade are believed to be crucial for the formation of the syncytiotrophoblast (STB) layer of the placenta. Moreover, human Syncytins harbor functional immunosuppressive domains, which could be implicated in the regulation of the maternal immune system during pregnancy. Similar results have been described for the equivalent murine Syncytin-A and -B in terms of their essential placental function. Furthermore, the biological function of Syncytin-1 and -2 might be linked through their presence on the surface of small extracellular vesicles, including exosomes. As important proteins for the development of the placenta, dysregulation of Syncytin-1 and -2 expression is linked to different pathologies, such as preeclampsia and HELLP syndrome. Human Syncytins are also associated to other diseases. Hence, the abnormal expression of these placenta-specific fusogenic proteins in other tissues has been linked to several different types of cancers. As Syncytin-1 and -2 are associated to exosomes, their levels could be monitored through analyses of blood-derived exosomes and thereby be used for early diagnosis of placental disorder or potentially monitoring the progression or aggressiveness of various cancers.
Fichier

Publications par entité

  • Centre de Formation et de Recherche en matière de Population (CEFORP) (15)
  • Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable (CIFRED) (18)
  • Chaire Internationale en Physique Mathématique et Applications (CIPMA-Chaire UNESCO) (16)
  • Ecole Nationale d'Administration et de Magistrature (ENAM) (47)
  • Ecole Nationle d'Economie Appliquée et de Management (81)
  • Ecole Normale Supérieure (24)
  • Ecole Polytechnique d'Abomey-Calavi (EPAC) (876)
  • Faculté de droit et de Science Politique (FADESP) (57)
  • Faculté des Lettres et Sciences Humaines (FLASH) (888)
  • Faculté des Sciences Agronomiques (1429)
  • Faculté des Sciences de la Santé (FSS) (1743)
  • Faculté des Sciences Economiques et de Gestion (FASEG) (143)
  • Faculté des Sciences et Techniques (FAST) (786)
  • Faculté des Sciences Humaines et Sociales (FASHS) (19)
  • Institut de Formation et de Recherche en Informatique (IFRI) (72)
  • Institut de Mathématiques et de Sciences Physiques (IMSP) (72)
  • Institut National de l'Eau (INE) (13)
  • INSTITUT NATIONAL DE LA JEUNESSE DE L’EDUCATION PHYSIQUE ET SPORT(INJEPS) (192)
  • Institut National des Métiers d'Art d'Archéologie et de la Culture (INMAAC) (4)
  • Institut National Médico Sanitaire ( INMeS) (0)
  • Institut Régional de Santé Publique (IRSP) (51)

Publications par sexe

  • Femme( 994 )
  • Homme (