Publications Scientifiques

[ Article ] Variability of antibiotic susceptibility and toxin production of Staphylococcus aureus strains isolated from skin, soft tissue, and bone related infections

Date de soumission: 20-02-2018
Année de Publication: 2013
Entité/Laboratoire
Document type : Article
Discipline(s) :
Titre Variability of antibiotic susceptibility and toxin production of Staphylococcus aureus strains isolated from skin, soft tissue, and bone related infections
Auteurs Sina Haziz [1], AHOYO THEODORA ANGÈLE [2], MOUSSAOUI WARDI [3], Keller Daniel [4], Keller Daniel [4], Keller Daniel [4], Keller Daniel [4], Keller Daniel [4], BANKOLE Honoré Sourou [5], BAB Lamine [7],
Journal: BMC Microbiology
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 13
DOI: doi:10.1186/1471-2180-13-188
Resume Background Staphylococcus aureus is an opportunistic commensal bacterium that mostly colonizes the skin and soft tissues. The pathogenicity of S. aureus is due to both its ability to resist antibiotics, and the production of toxins. Here, we characterize a group of genes responsible for toxin production and antibiotic resistance of S. aureus strains isolated from skin, soft tissue, and bone related infections. Results A total of 136 S. aureus strains were collected from five different types of infection: furuncles, pyomyositis, abscesses, Buruli ulcers, and osteomyelitis, from hospital admissions and out-patients in Benin. All strains were resistant to benzyl penicillin, while 25% were resistant to methicillin, and all showed sensitivity to vancomycin. Panton-Valentine leukocidin (PVL) was the most commonly produced virulence factor (70%), followed by staphylococcal enterotoxin B (44%). Exfoliative toxin B was produced by 1.3% of the strains, and was only found in isolates from Buruli ulcers. The tsst-1, sec, and seh genes were rarely detected (≤1%). Conclusions This study provides new insight into the prevalence of toxin and antibiotic resistance genes in S. aureus strains responsible for skin, soft tissue, and bone infections. Our results showed that PVL was strongly associated with pyomyositis and osteomyelitis, and that there is a high prevalence of PVL-MRSA skin infections in Benin.
Mots clés S. aureus, MRSA, PVL, Pyomyositis, Osteomyelitis, Skin infections, Benin, Africa
Pages 1 - 20
Fichier (PDF)

Publications par entité

  • Centre de Formation et de Recherche en matière de Population (CEFORP) (15)
  • Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable (CIFRED) (18)
  • Chaire Internationale en Physique Mathématique et Applications (CIPMA-Chaire UNESCO) (16)
  • Ecole Nationale d'Administration et de Magistrature (ENAM) (44)
  • Ecole Nationle d'Economie Appliquée et de Management (72)
  • Ecole Normale Supérieure (23)
  • Ecole Polytechnique d'Abomey-Calavi (EPAC) (835)
  • Faculté de droit et de Science Politique (FADESP) (45)
  • Faculté des Lettres et Sciences Humaines (FLASH) (789)
  • Faculté des Sciences Agronomiques (1376)
  • Faculté des Sciences de la Santé (FSS) (1613)
  • Faculté des Sciences Economiques et de Gestion (FASEG) (136)
  • Faculté des Sciences et Techniques (FAST) (748)
  • Faculté des Sciences Humaines et Sociales (FASHS) (16)
  • Institut de Formation et de Recherche en Informatique (IFRI) (68)
  • Institut de Mathématiques et de Sciences Physiques (IMSP) (61)
  • Institut National de l'Eau (INE) (13)
  • INSTITUT NATIONAL DE LA JEUNESSE DE L’EDUCATION PHYSIQUE ET SPORT(INJEPS) (191)
  • Institut National des Métiers d'Art d'Archéologie et de la Culture (INMAAC) (4)
  • Institut Régional de Santé Publique (IRSP) (51)

Publications par sexe

  • Femme( 908 )
  • Homme (