||The use of insecticides in malaria control programmes is expanding with the extensive and rapid roll out of long lasting insecticide treated bednets (LLINs) and indoor residual spraying (IRS). Just four classes of insecticides are available for mosquito control with only pyrethroids being suitable for impregnation of bednets. Resistance to each class of insecticide has been reported in malaria vectors and it is widely accepted that insecticide resistance can be responsible for vector control failures. The resistant allele ace-1R conferring cross resistance to organophosphates and carbamates in An. gambiae is now challenged by the recent occurrence of a new allele (ace-1D), putting in tandem a susceptible and a resistant copy of ace-1 on the same chromosome. Considering the importance to develop new strategies against resistant mosquitoes, and to preserve the effectiveness of the further vector control operations based on the use of insecticides, there are needs to develop improved tools for detection of these new mechanisms, to monitor them in wild populations and to understand how they are distributed in the field; and that is the main issues that will be addressed in this proposal.
This MIM proposal aims to develop a research program that will identify the major mechanisms of insecticide resistance and define their impact on current control methods and malaria transmission in Africa. The network consists of five research institutes (3 African and 2 Europeans) in three african countries. Each institute participation is relevant to the achievement of the proposal goals. Three master degrees and one PhD student will be involved and training in statistics with R project software will be done toward all scientists involved in this project. Yearly meetings will be held in Benin for the project monitoring.
Our proposed network will use this MIM project and existing links with other networks and research projects to strengthen capacity in effective resistance monitoring and management, experimental design and data interpretation across the African continent.