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[ Article ] Detection of poor quality artemisinin-based combination therapy (ACT) medicines marketed in Benin using simple and advanced analytical techniques

Date de soumission: 28-02-2018
Année de Publication: 2017
Entité/Laboratoire
Document type : Article
Discipline(s) :
Titre Detection of poor quality artemisinin-based combination therapy (ACT) medicines marketed in Benin using simple and advanced analytical techniques
Auteurs YEMOA Loconon Y. Achille [1], Habyalimana Védaste [1], Kindenge Mbinze Jeremie [2], SACRE Pierre-Yves [3], GBAGUIDI FERNAND [6], Quetin-Leclercq Joëlle [6], Djang’eing’a Marini Roland [6],
Journal: Current Drug Safety
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 12
DOI:
Resume Abstract: Background: Poor quality antimalarial medicines still represent a threat to the public health, especially in Sub-Saharan Africa who bears a disproportionate share of the global burden of malaria. It is essential and urgent to strengthen mechanisms against counterfeit medicines. One of the approaches is regular market surveillance through quality controls. Methods: 12 samples of artemether/lumefantrine were collected from formal and informal drug sellers in Cotonou (Benin) as well as additional other similar samples from Rwanda (13 samples) and from D.R. Congo (9 samples). Thin Layer Chromatography (TLC) as classical and simple identification test was applied in Benin while an analytical chemistry laboratory in Belgium (ULg, Pharmacy Department) was asked for further analyses with HPLC and Raman spectroscopy using a developed and validated HPLC method for rapid analysis of artemether/lumefantrine. Results: The results obtained in Belgium confirmed the lack of the two active ingredients in the suspected sample of ACT medicine from Benin whereas some samples from Rwanda and D.R. Congo were found to present risk of substandard drugs either for under-dosing or over-dosing. Conclusions: Counterfeit/falsified of artemisinin-based combination therapy (ACT) medicines are really scourge that needs to be fought through strong collaboration between public health authorities and appropriate quality control laboratories
Mots clés Poor quality medicines - artemether/lumefantrine – TLC – HPLC – Raman spectroscopy, ACT
Pages 178 - 186
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