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[ Article ] Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation and In Vitro Activity of Alkaloids Isolated from Holarrhena floribunda Used in Traditional Treatment of Buruli Ulcer

Date de soumission: 01-03-2017
Année de Publication: 2015
Entité/Laboratoire Laboratoire de Chimie Analytique et Analyse des Médicaments ( LCAM)
Document type : Article
Discipline(s) : Chimie Analytique et Bromatologie
Titre Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation and In Vitro Activity of Alkaloids Isolated from Holarrhena floribunda Used in Traditional Treatment of Buruli Ulcer
Auteurs YEMOA Loconon Y. Achille [1], Gbénou Joachin [2], AFFOLABI DISSOU [3], MANSOUROU Moudachirou [4], BIGOT KOFFI ANDRÉ [5], ANAGONOU-YEHOUENOU C. SÉVÉRIN [6], PORTAELS Françoise [7], MARTIN Anandi [8], Quetin-Leclercq Joëlle [9],
Journal: BioMed Research International
Catégorie Journal: Internationale
Impact factor: 1.579
Volume Journal: 2015
DOI: 10.1155/2015/835767
Resume Buruli ulcer (BU) imposes a serious economic burden on affected households and on health systems that are involved in diagnosing the disease and treating patients. Research is needed to find cost-effective therapies for this costly disease. Plants have always been an important source of new pharmacologically active molecules. Consequently we decided to undertake the study of plants used in traditional treatment of BU in Benin and investigate their antimycobacterial activity as well as their chemical composition. Extracts from forty-four (44) plant species were selected on account of reported traditional uses for the treatment of BU in Benin andwere assayed for antimycobacterial activities. Crude hydroethanolic extract fromaerial parts ofHolarrhena floribunda (G.Don) T. Durand and Schinz was found to have significant antimycobacterial activity againstM. ulcerans (MIC = 125
Mots clés Buruli Ulcer; Medicinal Plants; Antimycobacterial Agents; Bioguided Fractionation; in Vitro; Alkaloïds
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