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[ Article ] Development, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.

Date de soumission: 01-03-2017
Année de Publication: 2015
Entité/Laboratoire Laboratoire de Chimie Analytique et Analyse des Médicaments ( LCAM)
Document type : Article
Discipline(s) : Chimie Analytique et Bromatologie
Titre Development, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.
Auteurs Kindenge Mbinze Jeremie [1], SACRE Pierre-Yves [2], YEMOA Loconon Y. Achille [3], Habyalimana Védaste [5], Kalenda Nicodème [6], Hubert Philippe [7], Ziemons Eric [8],
Journal: Journal of Pharmaceutical and Biomedical Analysis
Catégorie Journal: Internationale
Impact factor: 2.98
Volume Journal: 111
DOI:
Resume Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient local drug analysis laboratories. To tackle part of this issue, two spectroscopic methods with the ability to detect and to quantify quinine dihydrochloride in children’s oral drops formulations were developed and validated. Raman and near infrared (NIR) spectroscopy were selected for the drug analysis due to their low cost, non-destructive and rapid characteristics. Both of the methods developed were successfully validated using the total error approach in the range of 50–150% of the target concentration (20% W/V) within the 10% acceptance limits. Samples collected on the Congolese pharmaceutical market were analyzed by both techniques to detect potentially substandard drugs. After a comparison of the analytical performance of both methods, it has been decided to implement the method based on NIR spectroscopy to perform the routine analysis of quinine oral drop samples in the Quality Control Laboratory of Drugs at the University of Kinshasa (DRC).
Mots clés Substandard drugs Counterfeit drugs NIR spectroscopy Raman spectroscopy Accuracy profiles
Pages 21 - 27
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