||The aim of this study was to evaluate the impact of the ethyl extract of dried leaves of Hexalobus monopetalus on
protein metabolism in Wistar rats. After a phytochemical screening of extracts, total protein, urea, uric acid and
creatinine were measured spectrophotometrically at six (06) sets of three (03) Wistar rats each. Batches 2 to 6 were
given with orally administered respectively the daily doses of: 0.25 mg / kg, 0.5mg / kg, 1mg / kg, 1.5mg / kg and 2.5mg
kg body weight of the extracts (for 14 days). The lot1 witness received distilled water instead of the extract. The results
of the phytochemical screening revealed the presence polyphenolic compounds (gallic tannins, catechin tannin or
condensed, anthocyanins, and leuco anthocyanins), flavonoids, mucilages reducing compounds, alkaloids, certain
anthracene derivatives ( free anthracene, the O-glycosides), Steroids, and quinone derivatives. It was observed a
significant increase (p ˂ 0.05) blood levels of total protein and uric acid and a significant (p ˂ 0.05) blood urea and
creatinine levels in treated plots to extracts. These observed variations did not depend on the administered dose of the
extracts but were depending on the duration of treatment; they were outstanding from the 7th day of treatment.
The long term use of ethyl extract of dried leaves of Hexalobus monopetalus could compromise the liver function and the
kidneys and may inhibit apoptosis in Wistar rats.