Publications Scientifiques

[ Article ] Hypotensive Activity of Tridax Procubens hydro ethanolic extract:Roles of transport of sodium and potassium in Rat Wistar.

Date de soumission: 14-02-2019
Année de Publication: 2018
Entité/Laboratoire Laboratoire de Biomembranes et Signalisation Cellulaire (LBSC)
Document type : Article
Discipline(s) : Biochimie, biophysique & Biologie Moléculaire
Titre Hypotensive Activity of Tridax Procubens hydro ethanolic extract:Roles of transport of sodium and potassium in Rat Wistar.
Auteurs MICHODJEHOUN Loetitia [2], Koukoui Omedine [1], Hoteyi Ismael [3], SEZAN ALPHONSE [4],
Journal: American Journal of PharmTech Research (AJPTR)
Catégorie Journal: Internationale
Impact factor: 1.123
Volume Journal: 8
Resume In Africa in general and Benin in particular the population is increasingly confronted with several pathologies such as hypertension. Even though modern medicine is well developed, this population uses traditional medicine because of its low purchasing power. But the lack of mastery of the dosage and its underlying effects remain archaic parameters and deserves special attention from the scientific world from which we have chosen to reflect on Tridax procumbens in order to come up with scientific arguments favorable to the promotion of the «Plant species. The present work was carried out in order to evaluate the effect of hydroethanolic extracts on the plasma and urinary concentrations of potassium, sodium and chloride ions in Wistar rats. After the preparation of the extracts and their gavage, the extraction yield was evaluated, the level of the K +, Na +, and Clions was assayed in three batches of three male Wistar rats. Lots 2 and 3 respectively received doses of 300 mg / kg and 500 mg / kg of single-dose PC in one day, respectively. Control batch 1 received distilled water in place of the extracts. At the same time, they were placed in cages with urine sampling, for the measurement of diuresis. The extraction yield by the hydroethanolic solvent was 16.75%. Extracts at a dose of 300 mg / kg of PC induced hyperkalaemia, with no effect on serum sodium and chloraemia within two hours of administration of the extracts. The diuresis is so insignificant that we can understand that hyperkalaemia, induced bradycardia arising from hyperpolarization of the cells of the pace maker. Its hypotensive property is therefore confirmed.
Mots clés Tridax procumbens, Ionic channels, Hyperkalemia, hypernatremia, Hyperchloremia, Diuresis, Hyperpolarization.
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