Publications Scientifiques

[ Article ] Clinical features and prognosis of amyotrophic lateral sclerosis in Africa: the TROPALS study.

Date de soumission: 25-02-2019
Année de Publication: 2019
Entité/Laboratoire
Document type : Article
Discipline(s) :
Titre Clinical features and prognosis of amyotrophic lateral sclerosis in Africa: the TROPALS study.
Auteurs Luna J [1], Diagana M. [2], Ait Aissa L [3], Tazir M [4], Ali Pacha L [5], Kacem I [6], Gouider R [0], Henning F [0], Basse A [0], Cisse O [0], Balogou B. S. [0], Kombate D [0],
Journal: J Neurol Neurosurg Psychiatry.
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 90
DOI: 10.1136/jnnp-2018-318469. Epub 2018 Sep 21
Resume OBJECTIVE: We describe and compare the sociodemographic and clinical features, treatments, and prognoses and survival times of patients with amyotrophic lateral sclerosis (ALS) in Africa. METHODOLOGY: We conducted a multicentre, hospital-based cohort study in Africa. Patients with ALS diagnosed in the neurology departments of participating hospitals from 2005 to 2017 were included. Subgroup analysis was performed by subcontinent. Survival analyses were conducted using the Cox proportional hazards model. RESULTS: Nine centres from eight African countries participated. A total of 185 patients with ALS were included: 114 from Northern Africa, 41 from Western Africa and 30 from Southern Africa. A male predominance (male to female ratio 2.9) was evident. The median age at onset was 53.0 years (IQR 44.5-64.0 years). The onset was bulbar in 22.7%. Only 47 patients (26.3%) received riluzole, mainly in Northern and Western Africa. The median survival from the time of diagnosis was 14.0 months (95% CI 10.7 to 17.2 months). The median survival was longer in Northern Africa (19.0 months, 95% CI 10.8 to 27.2 months) than in Western (4.0 months, 95% CI 0.8 to 7.1 months) and Southern (11.0 months, 95% CI 5.6 to 16.4 months) Africa (Breslow test, p<0.0001). Both subcontinental location and riluzole treatment independently affected survival. CONCLUSION: More African patients with ALS were male and younger and exhibited a lower proportion of bulbar onset compared with patients with ALS from Western nations. Survival was consistent with that in Western registers but far shorter than what would be expected for young patients with ALS. The research improves our understanding of the disease in Africa.
Mots clés Africa; amyotrophic lateral sclerosis; clinical features; prognosis; riluzole
Pages 20 - 29
Fichier

Publications par entité

  • Centre de Formation et de Recherche en matière de Population (CEFORP) (0)
  • Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable (CIFRED) (0)
  • Chaire Internationale en Physique Mathématique et Applications (CIPMA-Chaire UNESCO) (0)
  • Ecole Nationale d'Administration et de Magistrature (ENAM) (0)
  • Ecole Nationle d'Economie Appliquée et de Management (0)
  • Ecole Normale Supérieure (0)
  • Ecole Polytechnique d'Abomey-Calavi (EPAC) (0)
  • Faculté de droit et de Science Politique (FADESP) (0)
  • Faculté des Lettres et Sciences Humaines (FLASH) (0)
  • Faculté des Sciences Agronomiques (0)
  • Faculté des Sciences de la Santé (FSS) (0)
  • Faculté des Sciences Economiques et de Gestion (FASEG) (0)
  • Faculté des Sciences et Techniques (FAST) (0)
  • Faculté des Sciences Humaines et Sociales (FASHS) (0)
  • Institut de Formation et de Recherche en Informatique (IFRI) (0)
  • Institut de Mathématiques et de Sciences Physiques (IMSP) (0)
  • Institut National de l'Eau (INE) (0)
  • INSTITUT NATIONAL DE LA JEUNESSE DE L’EDUCATION PHYSIQUE ET SPORT(INJEPS) (0)
  • Institut National des Métiers d'Art d'Archéologie et de la Culture (INMAAC) (0)
  • Institut Régional de Santé Publique (IRSP) (0)

Publications par sexe

  • Femme( 908 )
  • Homme (