Publications Scientifiques

[ Article ] Effectiveness of the medicinal plant R019 in the treatment of HI V infection: an observational study

Date de soumission: 17-05-2019
Année de Publication: 2012
Entité/Laboratoire Laboratoire d'hématologie (LH)
Document type : Article
Discipline(s) : Immulogie & maladie infectueuse
Titre Effectiveness of the medicinal plant R019 in the treatment of HI V infection: an observational study
Auteurs ALLABI AUREL CONSTANT EUSTACHE [1], DJEIGO Julien Gaudence [2], YOMBI Jean-Cyr [3], DIOMBO Kouma [4], BIGOT KOFFI ANDRÉ [5], Giambattista PRIULI [6],
Journal: Journal of Applied Phannaceutica! Science
Catégorie Journal: Africaine
Impact factor: 0
Volume Journal: 2
DOI:
Resume This study aims to evaluate the in vivo antiviral, immunologie, clinical effects and safety of a supposedly anti-HIV phytotherapy, code-named ROl9 used for the treatment of HIV/AIDS. This is an open observational study, which involved 32 HIV-I infected patients, who were followed over a 3-month period. The efficacy evaluation was based on CD4 count, determination of viral 10ad and c1inical status. The safety eva1uation was based on renal and liver function tests, fasting lipid and glycaemia levels as weil as the frequency of other adverse events. The CD4 values increased significantly (mean±SD, 99.03±22.87 cellsl~l; P<O.OOI), as weil as Weight and Karnofsky score (2.94±O.67 kg, p<O.OOI; 4.9, p=O.005 respectively). The viral load decreased significantly (O.91±O.12 log viral load, P<O.OOO 1). RO 19 did not impair renal or liver functions. Improvement of creatinine clearance was observed (p=O.02). Hemoglobin levels increased (0.38±O.l6 gr/dl) whereas cholesterol and glucose levels decreased under R019 treatinent (p=O.031, p=O.018 respectively). Main adverse effects were recorded: polyuria (40.5%), drowsiness (21.4%), orexis (19.1%). Immunological, anti-viral and c1inical status improved under RO 19 treatment and a good safety profile was observed for this compound. Further studies wouId he required to optimize its efficacy and to define its appropriateness for the treatment of HIV disease.
Mots clés ROl9, HIV infection, Efficacy, Safety
Pages 59 - 65
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