| Titre |
Antimycobacterial screening of plants from Benin on Mycobacterium ulcerans, the causal agent of Buruli ulcer.............. |
| Auteurs |
Yemoa Achille [1],
MARTIN Anandi [2],
AFFOLABI DISSOU [3],
GBENOU DJ [4],
MOUDACHIROU MANSOUROU [5],
ANAGONOU-YEHOUENOU SEVERIN [6],
PORTAELS Françoise [7],
Quetin-Leclercq Joëlle [8],
|
| Journal: |
West Atrican Journal of Research for Health |
| Catégorie Journal: |
Africaine |
| Impact factor: |
0 |
| Volume Journal: |
3 |
| DOI: |
|
| Resume |
Abstract: The purpose 01 this study is to investigate
the antimycobacterial activit)' against Mycobacterillm
II/cerans of plants used in traditional medicine in Benin
to treat Buruli uleer (BU). Out of 49 plants identified,
44 were seJected and screened. erude extracts
of leaves, fruit seeds, and roots were prepared and
the minimum inhibitory concentration (MIC) values
were deterrnined using an adapted Resazurin
Microtiter Assay (REMA). The cruùe extracts of
Holarrhenn floribu71dn (G.Don) T. Durand and Schinz
and Jatroplta curcas Linn showed inhibitory activity
against M. ufceralls at concentrations of 125 and 250
"g/ml respectively. The adapted REMA method
used in this study to de/ermine the MIC values of
natural product is simple, sensitive, and rapid, and
could be a method of choice to successfully assess
antibacteriaI properties of plants extracts against
M. ulcerans. This can also contribute to document
traditional treatment of IlU. |
| Mots clés |
Keywards: B"rll/i IIleer; Traditiolla/medicine; Medicinal
plants; Alltimycobacteriat activily; Benin. |
| Pages |
15 - 18 |
| Fichier |
(PDF) |