Feuilleter BEC-UAC par
Publications par type
- Article (9714)
- Brevet (6)
- Communication (360)
- Documents de valorisation (6)
- Documents de vulgarisation (4)
- Fiches Techniques (33)
- Livre (277)
- Memoire (17)
- Poster (61)
- Projet (9)
Qualité des articles
- Impact Factor(2560)
- Indexé (2875)
- Comité de lecture (3607)
- Autre (177)
Liens utiles
Publications Scientifiques
[ Article ] ln vivo To~icological Assessment of the Aqueous Extracts of the Leaves of Carissa edulis (Apocynaceae) in Wistar Rats.......o
| Date de soumission: | 17-05-2019 |
|---|---|
| Année de Publication: | 2016 |
| Entité/Laboratoire | Laboratoire d'hématologie (LH) |
| Document type : | Article |
| Discipline(s) : | Immulogie & maladie infectueuse |
| Titre | ln vivo To~icological Assessment of the Aqueous Extracts of the Leaves of Carissa edulis (Apocynaceae) in Wistar Rats.......o |
|---|---|
| Auteurs | Osseni Razack [1], AKOHA STEPHEN [2], ADJAGBA Marius [3], AZONBAKIN AZANDÉGBÉ SIMON [4], LAGNIKA LATIFOU [5], BIGOT KOFFI ANDRÉ [6], Awede Bonaventure [7], AMADOU DIOUF [8], Darboux Raphael [9], LALEYE OLABISSI ANATOLE A. [10], |
| Journal: | European Journal of Medicinal Plants |
| Catégorie Journal: | Internationale |
| Impact factor: | 0 |
| Volume Journal: | 15 |
| DOI: | |
| Resume | Aim: To screen the acute a!1d 28-days subchronic toxicity of the leaves aqueous extract of Carissa edulis (C. edulis). Design: Experimental and observational study. Place and Duration: Faculty of health sciences of Cotonou / Institute of Applied Biomedical Sciences of Cotonou, laboratories of Physiology/Human biologyllmmunology/ biochemistry and molecular biology( pharmacognosy section) / toxicology and hydrology of Dakar (Senegal) between March 2014 and January 2015. Methods: The aqueous extract was obtained from the powder of the leaves by a decoction method and evaporation using a rotavapor. In the acute toxicity study (Limit test), a single dose of 2000 mg/kg of the extract was -«'Jrally administered to three female rats. Different parameters were assessed according to the Organisation for Economic Co-operation and Development (OECD) 423 guidelines for the Testing of Chemicals. During the sub-chronic toxicity, four groups of five rats of either sex received distilled water (control), 31.25,125 and 500 mg/kg of the extract daily for 28 consecutive days by oral gavage. The assay was conducted according to the OECD 407 guidelines. Results: ln both acute and sub-chronic toxicity test, neither mortality nor other toxicity symptoms were observed. This suggests that the median Lethal Dose 50 (LDso) is superior to 2000 mg/kg. There were no significant differences in the body and organ weights between controls and treated animais of both sexes. Indeed, sorne biological parameters including erythrocytes (6,89±0,07), Haematocrit (41 ,6±1 ,69), and Haemoglobin (13,31 ±O,16) levels were significantly reduced when compared to the control group but this is not imputable pathologically. Histological structures of liver and kidney were normal in both two sexes. Conclusion: The aqueous extract of C. edulis was found to be safe in acute and 28-days subchronic toxicity studies. Furthermore, aspects of the effects of this plant on haematopoiesis, Iiver and kidney function need to be gained and ascertained over longer periods of toxicity study. |
| Mots clés | Carissa edu/is; toxicity; Wistar rats; L05o• |
| Pages | 1 - 10 |
| Fichier |  (PDF) |
Publications par entité
- Centre de Formation et de Recherche en matière de Population (CEFORP) (0)
- Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable (CIFRED) (0)
- Chaire Internationale en Physique Mathématique et Applications (CIPMA-Chaire UNESCO) (0)
- Ecole Doctorale Pluridisciplinaire <<Espaces, Culture et Développement>> (0)
- Ecole Nationale d'Administration et de Magistrature (ENAM) (0)
- Ecole Nationle d'Economie Appliquée et de Management (0)
- Ecole Normale Supérieure (0)
- Ecole Polytechnique d'Abomey-Calavi (EPAC) (0)
- Faculté de droit et de Science Politique (FADESP) (0)
- Faculté des Lettres et Sciences Humaines (FLASH) (0)
- Faculté des Lettres, Langues, Arts et Communications (FLLAC) (0)
- Faculté des Sciences Agronomiques (0)
- Faculté des Sciences de la Santé (FSS) (0)
- Faculté des Sciences Economiques et de Gestion (FASEG) (0)
- Faculté des Sciences et Techniques (FAST) (0)
- Faculté des Sciences Humaines et Sociales (FASHS) (0)
- Institut de Formation et de Recherche en Informatique (IFRI) (0)
- Institut de Géographie de l'Aménagement du territoire et de l'Environnement (IGATE) (0)
- Institut de Mathématiques et de Sciences Physiques (IMSP) (0)
- Institut National de l'Eau (INE) (0)
- INSTITUT NATIONAL DE LA JEUNESSE DE L’EDUCATION PHYSIQUE ET SPORT(INJEPS) (0)
- Institut National des Métiers d'Art d'Archéologie et de la Culture (INMAAC) (0)
- Institut National Médico Sanitaire ( INMeS) (0)
- Institut Régional de Santé Publique (IRSP) (0)
Publications par sexe
- Femme( 0 )
- Homme ( 0 )
Publications Globales
- Total publications(0)