Publications Scientifiques

[ Article ] Quality control and interest of the determination of anti-CCP antibodies and rhellmatoid factor in the diagnosis of rheumatoid arthritis..,:

Date de soumission: 17-05-2019
Année de Publication: 2016
Entité/Laboratoire Laboratoire d'hématologie (LH)
Document type : Article
Discipline(s) : Immulogie & maladie infectueuse
Titre Quality control and interest of the determination of anti-CCP antibodies and rhellmatoid factor in the diagnosis of rheumatoid arthritis..,:
Auteurs AMOUSSOU NATHALIE GISELE [1], GOUNONGBE MARCELLE COLETTE MARIE [2], DOUGNON T. VICTORIEN [3], ZOMALHETO COSSI ZAVIER [4], LOKO CHRISTIAN FRÉDÉRIC SIMPLICE [5], BIGOT KOFFI ANDRÉ [6],
Journal: Asian journal of Medical and Biological Research
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 2
DOI:
Resume Abstract: The rheumatoid arthritis (RA) is an auto-immune, rheumatic and chronic inflammatory diseàse, characterized by joints damage. The early diagnosis of RA allows the initiation of a treatment which offers to the patients more chance of remission and avoids the evolution towards the unrecoverable deformity of joints. The objective of this study is t'J 2valuate the perfonnance of recent tests for the determinatiol"i oC anti -CCP antibodies and FR by ELISA in Benin Republic. This analytical, retrospective (2 years 6 months) and prospective (7 months) study allowed us to collect 36 patients meeting the American College of Rheumatology (ACR) criteria for RA and 24 controls. A comparison was made with the latex agglutination test for rheumatoid factors and a search of rheumatoid factors (RF) on the one hand and anti-cyclic citrullinated peptide. In our study, the specificity of anti-CCP assay (100 %) is higher than that of RF-ELISA (91.7%). The sensitivity of RF-ELISA assay is higher (77.8 %) than that of anti-CCP assay (66.7%). The latex test for rheumatoid factors has a sensitivity of 33.3 %. The positive predictive value (PPV) of anti-CCP assay (100 %) is higher than that of RF-ELISA assay (93.33 %). The positive-likelihood ratio (LR+) of anti-CCP assay is higher than the LR+ of RF-ELISA assay (4.96). The negative-likelihood ratio (LR-) of anti-CCP assay (0.33) is higher than the LR- of RF-ELISA assay (0.24). In conclusion', the anti-CCP assay has the highest specificity and RF -ELISA assay shows the highest sensitivity. In conclusion, the association of the two assays enhances a better diagnosis value for RA.
Mots clés anti-CCP rheumatoid factor; rheumatoid arthritis; biological diagnosis
Pages 379 - 388
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