||Modification of biochemical and haematological parameters d~ring 90-days subchronic toxicity assessment of Carissa edulis in Wistar rats....
Osseni Razack ,
ADANLE Etienne ,
ADJAGBA Marius ,
AWEDE BONAVENTURE L. SÉVERIN ,
HOUNTOHOTEGBE Tatiana ,
BIGOT KOFFI ANDRÉ ,
DARBOUX Raphael ,
LALEYE OLABISSI ANATOLE A. ,
||Journal of Toxicology and Environmental health Sciences
||A 90-days subchronic toxicity assay was evaluated on the aqueous extract of Carissa edulis leaves.
Wistar rats were fed daily with oral doses of 125, 31.25 and 7.87 mg/kg of C. edulis leaves extracts.
Toxic effects were assessed using physiological observation, body weight, relative organ weights, feed
consumption, biochemical, haematological and histopathological parameters. Many changes of
biological values were observed among treated rats versus controls. Although, alterations in
biochemical parameters including aspartate amino transferase were observed, in the middle of
treatment (day 45), the values were physiologically normalized at the end of the study. Changes were
observed also among renal function parameters including increased levels of creatinine, urea and ions
disorders. These results were. related by the histopathological examinations. The haematologicaJ
analysis showed an increase in erythrocytes cou nt, haemoglobin, haematocrit (polyerythrocythemia)
associated with an increase of MGV level (macrocytosis). These observations suggest that the longterm
uses of Carissa edulis could alter sorne functions of the organism, especially the hepatic, renal
and haematopoietic f netions. Further specifie toxicity studies must be investigated on the plant.
||Carissa edulis, polyerthrocythemia, subchronic toxicity, Wistar rats.
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