Publications Scientifiques

[ Article ] Surface active properties of lipid nanocapsules

Date de soumission: 21-05-2019
Année de Publication: 2017
Entité/Laboratoire Laboratoire d'hématologie (LH)
Document type : Article
Discipline(s) : Immulogie & maladie infectueuse
Titre Surface active properties of lipid nanocapsules
Auteurs MOUZOUNVI Celia [1], Umerska Anita [2], BIGOT KOFFI ANDRÉ [3], Saulnier Patrick [4],
Journal: PLUS ONE
Catégorie Journal:
Impact factor: 0
Volume Journal: 0
Resume Lipid nanocapsules (LNCs) are biomimetic nanocarriers used for the encapsulation of a broad variety of active Ingredients. Similar to surface active com pounds, LNCs contain both hydrophilic and hydrophobic parts in their structure. Moreover, the components of LNCs, macrogol 15 hydroxystearate (MHS) and lecithin, are known for their surface active properties, Therefore, the aim of this paper was to investigate the capability of the LNCs to decrease surface tension using two techniques: drop tensiometry and the Wilhelmy plate method. LNCs with diameters ranging from 30 to 100 nm were successfully obtained using a phase inversion technique. The LNCs' properties, such as size and zeta potential, depend on the compOSition. LNCs exhibit a lower limiting surface tension compared to MHS (34.8-35.0 mN/m and 37.738.8 mN/m, respectively), as confirmed by both drop tensiometry and the Wilhelmy plate methoçl. LNCs have exhibited a saturated interfacial concentration (SIC) that was 10-fold higher than the critical micellar concentration (CMC) of MHS orthe SIC of binary and ternary mixtures of LNC ingredients. The SIC of the LNC formulations depended on the mass mixing ratio 01 the MHS/triglycerides but not on the presence of lecithin. The CMC/SIC vJ!C!es measured by the Wilhelmy plate method were higher than those obtained using drop tensiometry because of the longer duration of the tensiometry measurement. In conclusion, the surfactantlike properties of the LNCs olier new possibilities for medical and pharmaceutical applications.
Mots clés nanocapsules
Pages 1 - 19
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