||First detection of human T-Iymphotropic virus in blood donors in Benin shows that testing is required to improve blood safety...
Amoussa Adjile Edjide Roukiyath ,
Kashima Simone ,
Djobessi Didier ,
Barreto Fernanda Khouri ,
Davou Denise ,
BIGOT KOFFI ANDRÉ ,
ANANI LUDOVIC YAOVI ,
Lourenço Jose ,
Giovanetti Marta ,
Sabino Ester ,
RAHIMY MOHAMED CHÉRIF DEEN ,
Alcantara Luiz Carlos Junior ,
||International Society of Blood Transfusion
||Introduction Human T-Iymphotropic virus (HTLV) is a blood-borne infection that
can be transmitted via blood transfusion. Knowing that blood safety can improve
blood transfusion to prevent dissemination of viral infections in medical facilities,
there is no routine pre-transfusion screening for HTLV in ail blood banks in
the Republic of Benin. This study aims to estimate the prevalence of HTLV infection
in blood donors and describes the characteristics of positive donors.
Methods A HTLV prevalence study was carried out by screening 2,035 samples
by an enzyme-linked immunoassay obtained from six blood banks located
throughout the Republic of Benin. The PCR method was used to conflrm and type
ail the ELISA reactive samples.
Results and discussion Twelve subjects, ail volunteer blood donors, were found
with positive serology confirmed by a specifie HTLV type 1 PCR assay, representing
an overall seroprevalence of 0·59%. Furthermore, seven subjects were indeterminate
for anti-HUV-l/2 antibody and only one sample was confIrmed
positive for HTLV type 1 in a PCR reaction. These are the flfSt cases of HUV
detection among blood donors in Benin Republic, whose blood was already
transfused to recipients. This result emphasizes that HUV needs to be considered
as a Public Health issue in the Republic of Benin.
Conclusion This study reports positive result of HUV infection among blood
donors in the blood banks of Benin Republic in West Africa and highlights the
inclusion of screening tests and strategies to reduce its transmission.
||Blood donors, HTLV, HTLV prevalence, HUV testing.
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