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[ Article ] Epidemiological, Clinical and Evolutionary Profile of Toxidermias in the Dermatology-Venereology Department of the Army Training Hospital/University Hospital Center (HIA/CHU) of Cotonou, Benin

Date de soumission: 10-02-2020
Année de Publication: 2018
Entité/Laboratoire
Document type : Article
Discipline(s) :
Titre Epidemiological, Clinical and Evolutionary Profile of Toxidermias in the Dermatology-Venereology Department of the Army Training Hospital/University Hospital Center (HIA/CHU) of Cotonou, Benin
Auteurs Agbessi Nadège [1], AKPADJAN GBEMAWONMEDE FABRICE [2], Koudoukpo Christiane [3], DEGBOE BÉRÉNICE [4], d’ALMEIDA CHRISTELLE [5], Atadokpede Felix [6],
Journal: Clinical Research in Dermatology
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 1
DOI:
Resume ABSTRACT Introduction: Toxidermias are mucocutaneous complications secondary to the enteral, intravenous, subcutaneous, or intramuscular administration of drugs. They have a high semiological variability. The objective of this study was to determine the epidemiological, clinical, and evolutionary characteristics of toxidermias in a hospital population in Cotonou. Patients and Methods: This was a cross-sectional study with a descriptive, retrospective aim, which took place from January 1, 2012, to June 30, 2017, in the Dermatology-Venereology Department of the Army Training Hospital/University Hospital Centre (HIA/CHU) of Cotonou, Benin. Results: A total of 45 cases of toxidermias were diagnosed, representing a frequency of 0.62%. A female predominance with a sex ratio =1.2 was noted. The average age was 36.2 ± 19.4 years. Antibiotics whose sulfonamides were the most implicated drugs in the occurrence of toxidermias. Hyperpigmented macules were found in 46.66% of patients. Fixed pigmented erythema was diagnosed in 35.5% of patients and was the most frequent toxidermy, 62.22% of our patients were cured, and 33.33% were lost to follow-up. Conclusion: Drug-induced skin reactions are not negligible and fixed pigmented erythema is the predominant clinical form of this disease in Cotonou.
Mots clés Benin, clinical, epidemiology, evolution, toxidermy
Pages 1 - 3
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