Titre |
CHEMICAL COMPOSITION, ANTIHYPERTENSIVE ACTIVITY AND IN VIVO TOXICITY OF LEAVES EXTRACTS OF TWO BENINESE MEDICINAL PLANTS |
Auteurs |
TOKOUDAGBA JEAN MARIE [1],
ADJAGBA Marius [2],
Gandonou Clément [3],
Awede Bonaventure [4],
LALEYE OLABISSI ANATOLE A. [0],
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Journal: |
INTERNATIONAL JOURNAL OF CURRENT MEDICAL AND PHARMACEUTICAL RESEARCH |
Catégorie Journal: |
Internationale |
Impact factor: |
4.656 |
Volume Journal: |
4 |
DOI: |
|
Resume |
The characterization of chemical constituents of alcohol-water extracts of Parkia biglobosa and
Spondias mombin leaves revealed the presence of the following two important chemical groups:
catechical tannins, reducing compounds and mucilage. Gallic tannins, flavonoids, leucoanthocyans,
combined anthracenic derivatives (C-Heterosids), coumarin are found only in Parkia biglobosa
leaves and saponosids are present only in Spondias mombin leaves. The alcohol-water extracts of
Parkia biglobosa and Spondias mombin revealed in vivo an anti-hypertensive action respectively 171
mm Hg to 143 mm Hg, and 171 mm Hg to 154 mm on the rats whose blood pressure is higher than
normal provoked by the L-NAME at the dose of 20mg/Kg/J. The anti-hypertensive effect of Parkia
biglobosa crude extract is more important than the one of Spondias mombin crude extract. The study
of acute toxicity of the two extracts carried out on NMRI mice allowed to classify these two species
in the class III of World Health Organization (WHO): class of slightly toxic extracts with a lethal dose (LD 50 limit) higher than 2000mg/Kg |
Mots clés |
Parkia biglobosa, Spondias mombin,
alcohol-water extract, anti-
hypertensive activity, toxicity. |
Pages |
3820 - 3823 |
Fichier |
(PDF) |