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[ Article ] Assessment of serum cystatin C in the early detection of Type 2 diabetic nephropathy in cotonou, benin

Date de soumission: 13-02-2020
Année de Publication: 2019
Entité/Laboratoire Unité de Médécine Interne (UMI)
Document type : Article
Discipline(s) : Urologie & Néphrologie
Titre Assessment of serum cystatin C in the early detection of Type 2 diabetic nephropathy in cotonou, benin
Auteurs AGBOTON BRUNO [3],
Journal: African Journal of Nephrology
Catégorie Journal: Africaine
Impact factor: 0
Volume Journal: 22
DOI:
Resume Introduction: Diabetic nephropathy is a frequent and dreaded complication of diabetes mellitus. The purpose of this work was to study the role of serum cystatin C in the early detection of diabetic nephropathy among type 2 diabetic patients. Methods: This was a cross-sectional study conducted in Cotonou over a period of six months. Blood samples were tested at the regional food safety testing analysis laboratory. Type 2 diabetic patients older than 15 years, who gave their informed consent, were included in the study. Patients with proven proteinuria, acute kidney injury, haematuria, a positive urine test for nitrite, or reduced glomerular filtration rate <60 mL/min/1.73 m2 were excluded from the study. All patients were subjected to serum cystatin C and microalbuminuria assays. Results: Eighty-eight patients were included in the study. Their average age was 50.7 ± 9.6 years and the male to female ratio was 1.4:1. Twenty-four-hour microalbuminuria was positive in 53 (60%) cases whereas serum cystatin C tested positive in only 2 cases. Sensitivity and specificity tests applied to cystatin C showed very low sensitivity (4%) with a positive predictive value of 100% and high specificity (100%) with a negative predictive value of 41%. Conclusions: When compared with 24-hour microalbuminuria, serum cystatin C assay was not sensitive enough to prove suitable for screening for diabetic nephropathy. Serum cystatin C would therefore not be useful for the early detection of nephropathy among type 2 diabetic patients.
Mots clés Benin; cystatin C; CKD screening; microalbuminuria; diabetic nephropathy.
Pages 17 - 20
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