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[ Article ] Treatment of Hepatitis C with Pegylated Interferon Alpha-2a and Ribavirin: Experience from Benin
| Date de soumission: | 29-02-2020 |
|---|---|
| Année de Publication: | 2018 |
| Entité/Laboratoire | Unité d'Hépathogastro-Enthérologie (UHE) |
| Document type : | Article |
| Discipline(s) : | Gastroantérologie & Hépatologie |
| Titre | Treatment of Hepatitis C with Pegylated Interferon Alpha-2a and Ribavirin: Experience from Benin |
|---|---|
| Auteurs | KPOSSOU ABOUDOU RAÏMI [1], SEHONOU JEAN [2], ADJIGBE G.M. Géraud [3], VIGNON KOFFI RODOLPH [4], Sake Alassan Khadidjatou [5], KODJOH NICOLAS [6], |
| Journal: | Open Journal of Gastroenterology |
| Catégorie Journal: | Internationale |
| Impact factor: | 0 |
| Volume Journal: | 8 |
| DOI: | 10.4236/ojgas.2018.88030 |
| Resume | Background: Viral hepatitis C (HCV) is common in Benin. Untreated, it can be complicated by cirrhosis and hepatocarcinoma, which are sources of death. The objectives of this work were twofold: 1) to evaluate the effectiveness and safety of treatment with classic dual interferon pegylated a lpha-2a (IFN) and ribavirin t herapy i n B enin, a nd 2) t o p resent p roblems r elated t o fi nancial accessibility to this treatment. Methods: This was a cross-sectional, descriptive and analytical study, with a retrospective collection of data from November 1, 2010 to December 31, 2015 and prospective collection from January 1, 2016 to J uly 3 1, 2 016 ( 7 m onths).W e i ncluded a ll p atients t reated wi th IF N + ribavirin fo r h epatitis C a t CN HU/HKM. S ustained vi rological r esponse (SVR) w as d efined a s u ndetectable vi ral l oad C 6 months aft er st opping treatment. Safety was appreciated by the search for clinical and hematological adverse ef fects. Results: One h undred and si x patients w ere f ollowed f or HCV, o f w hom 5 8 ( 54.7%) undergoing t reatment ( 26 u nder st andard d ual therapy a nd 32 u nder d irect-acting antivirals). O f t he 2 6 patients under- conventional dual therapy, 12 (46.1%) were genotype 1, 13 (50%) genotype 2 and one (3.9%) genotype 4 . In conventional dual therapy, SVR was achieved in 15 (57.7%) patients, including the genotype 4 patient, 4 out of 12 (33.3%) genotype 1 patients, and 10 out of 13 (76.9%) for genotype 2 patients. The most common side effects with this treatment were severe asthenia (23 cases), flu-like s ymptoms ( 22 c ases), w eight l oss ( 21 c ases) a nd n eutropenia ( 22 cases), ane mia and thrombocytopenia (20 o f 2 6 cases). T he overall c ost o f treatment p er p atient w as 11,800,624 F CFA fo r g enotypes 1 a nd 4 ; and 7,835,048 F CFA f or g enotype 2. Conclusion: The t reatment o f HCV w ith IFN + ribavirin in Benin is effective for genotype 2. But its adverse effects are manifold and i ts c ost is hi gh. The s witch t o d irect-acting ant ivirals (more effective, better tolerated and less expensive) was therefore necessary. |
| Mots clés | Hepatitis C, Pegylated Interferon Alpha-2a, Ribavirin, Effectiveness, Safety, Cost |
| Pages | 275 - 283 |
| Fichier |  (PDF) |
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