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[ Article ] Bacteriologically Confirmed Neuromeningeal Tuberculosis at the Hubert Koutoukou Maga National Hospital and University Center in Cotonou: About Two Cases Study and a Review of the Literature

Date de soumission: 07-02-2021
Année de Publication: 2020
Entité/Laboratoire Unité de Médécine Interne (UMI)
Document type : Article
Discipline(s) : Médécine Générale et interne
Titre Bacteriologically Confirmed Neuromeningeal Tuberculosis at the Hubert Koutoukou Maga National Hospital and University Center in Cotonou: About Two Cases Study and a Review of the Literature
Auteurs AZON-KOUANOU Angèle [1], AGBODANDE KOUÉSI ANTHELME [2], Dodo leoubou Roger Samuel [3], Missiho Mahoutin Semassa Ghislain [4], Prudencio Roberto Dossou Tores Kouassi [5], Murhula Delphin [6], Doukpo Marius [7], Dansou Eugénie [8], LOKOSSOU THOMAS COMLAN [9], ZANNOU DJIMON MARCEL [10], HOUNGBE FABIEN [11],
Journal: open journal
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 10
DOI: DOI: 10.4236/ojim.2020.102020
Resume Introduction: Tuberculosis remains a major public health problem. The damage to the central nervous system is severe. We reported here two cases. Clinical Case 1: A 37-year-old female patient, naively Human Immunodeficiency Virus1 (HIV1)-positive with antiretroviral (ARV) treatment, hospitalized in the Internal Medicine department for altered consciousness in a febrile context. The clinical examination at admission noted a meningeal syndrome. Cytological analysis of the cerebrospinal fluid (CSF) revealed lymphocytic meningitis with 98% lymphocytes for 3634 leukocytes. CSF polymerase chain reaction (PCR) detected Mycobacterium tuberculosis DNA. She was put on anti-tuberculosis treatment. The immediate course was favourable, but a secondary worsening of the clinical picture was the cause of his death. Clinical Case 2: A 34-year-old male patient, naively HIV1-positive with ARV treatment. He is hospitalized in the Multi-Purpose Anaesthesia and Resuscitation Department of the CNHU HKM for altered consciousness in a feverish context. The clinical examination noted a meningeal syndrome. The cytological analysis of the CSF noted 184 leukocytes for 99% lymphocytes. The CSF PCR identified the DNA of Mycobacterium tuberculosis . He was put on anti-tuberculosis treatment. The evolution was marked by his death. Con clusion: The neuromeningeal localization of tuberculosis is a poor prognosis. Co-infection with HIV remains a potential deadly combination.
Mots clés Neuromeningeal Tuberculosis, HIV Infection, Death, Cotonou
Pages 190 - 197
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