Publications Scientifiques

[ Article ] Development of new dermatological formulations for the treatment of cutaneous candidiasis

Date de soumission: 09-02-2021
Année de Publication: 2020
Entité/Laboratoire Laboratoire de Chimie Organique et Pharmaceutique (MOCL)
Document type : Article
Discipline(s) : Pharmacie, Pharmacologie & Toxicologie
Titre Development of new dermatological formulations for the treatment of cutaneous candidiasis
Auteurs ASSANHOU Assogba Gabin [2],
Journal: Scientific African
Catégorie Journal: Internationale
Impact factor: 0
Volume Journal: 8
Resume The inhibitory activity of the essential oils (EO) of mint and thyme on Candida albicans are well known, however, their valorization in a dosage form for the management of cutaneous candidiasis has been little explored. This study aimed to formulate innovative and cost-effective dermatological topicals based on mint and thyme essential oils for the treatment of cutaneous candidiasis. Thyme essential oil was obtained commercially, while that of mint was obtained by hydrodistillation. In order to determine their antifungal activity, both essentials oils were tested alone and in combination against a reference strain of Candida albicans (strain MHMR) and clinical strains of Candida albicans and Candida tropicalis. Three creams were formulated using natural (shea butter, palm oil) and chemical (cetomacrogol) excipients. The efficacies of these creams were assessed in vivo using Wistar rats infected with Candida albicans MHMR. The in vitro antimicrobial study showed that C. albicans MHMR was more sensitive to thyme essential oil with a MIC of 310 μgmL−1, which was higher than the reference fluconazole used for the in vitro study (32 μgmL−1). The antimicrobial synergy study of both essential oils using checkerboard test demonstrated an additive effect of mint and thyme essential oils on C. albicans MHMR. GC/FID and GC/MS analyses led to the identification of thymol and menthol respectively as the main components of thyme and mint essential oils. A shea butter cream base and a shea butter and palm oil cream both containing 5% of EO (mint and thyme) exhibited the best in vivo antimicrobial activities, inducing optimal wound healing in infected rats compared with ketoconazole commercial cream used for the in vivo study. These results provide a solid basis at least in part, for the use of essential oil in creams formulated with natural excipients for the management of cutaneous candidiasis.
Mots clés Essential oilShea butter creamThymeMintCandida albicans
Pages -

Publications par entité

  • Centre de Formation et de Recherche en matière de Population (CEFORP) (21)
  • Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable (CIFRED) (43)
  • Chaire Internationale en Physique Mathématique et Applications (CIPMA-Chaire UNESCO) (45)
  • Ecole Doctorale Pluridisciplinaire <<Espaces, Culture et Développement>> (0)
  • Ecole Nationale d'Administration et de Magistrature (ENAM) (73)
  • Ecole Nationle d'Economie Appliquée et de Management (88)
  • Ecole Normale Supérieure (35)
  • Ecole Polytechnique d'Abomey-Calavi (EPAC) (1127)
  • Faculté de droit et de Science Politique (FADESP) (116)
  • Faculté des Lettres et Sciences Humaines (FLASH) (1385)
  • Faculté des Lettres, Langues, Arts et Communications (FLLAC) (0)
  • Faculté des Sciences Agronomiques (1949)
  • Faculté des Sciences de la Santé (FSS) (2344)
  • Faculté des Sciences Economiques et de Gestion (FASEG) (191)
  • Faculté des Sciences et Techniques (FAST) (1084)
  • Faculté des Sciences Humaines et Sociales (FASHS) (70)
  • Institut de Formation et de Recherche en Informatique (IFRI) (76)
  • Institut de Géographie de l'Aménagement du territoire et de l'Environnement (IGATE) (0)
  • Institut de Mathématiques et de Sciences Physiques (IMSP) (124)
  • Institut National de l'Eau (INE) (28)
  • Institut National des Métiers d'Art d'Archéologie et de la Culture (INMAAC) (12)
  • Institut National Médico Sanitaire ( INMeS) (0)
  • Institut Régional de Santé Publique (IRSP) (84)

Publications par sexe

  • Femme( 1411 )
  • Homme (