||Métabolites secondaires et activités biologiques des extraits de l’écorce de tronc de Khaya senegalensis, une plante à usage vétérinaire récoltée au Bénin
KOUDORO YAYA ALAIN ,
Agbangnan D. Pascal Cokou ,
Bothon Diane ,
Bogninou Sophie Reine ,
ALITONOU GUY ALAIN ,
Avlessi Felicien ,
Sohounhloue Codjo Koko Dominique ,
||International Journal of Innovation and Applied Studies
||: In Africa, and particularly in Benin, medicinal plants are the most widely used means of solving human and animal
health problems. The Beninese flora is rich in plants used to treat gastrointestinal diseases of farm animals whose chemical
and biological potentials are still unknown. It is to correct this insufficiency that the present work aims at the chemical and
biological recovery of Khaya senegalensis. After phytochemical screening, the phenolic compound contents of Khaya
senegalensis extracts were determined spectrophotometer. Antibacterial and antiradical activities were evaluated by
microplate dilution methods and DPPH respectively. The active ingredients of K. senegalensis were characterized by GC/MS.
Several metabolites have been identified. The crude extracts (ethanolic, hydroethanolic and aqueous extracts) of K.
senegalensis showed a lower antiradical activity compared to ethyl ether (IC50=0.09 μg/ml) and ethyl acetate (IC50=1μg/ml)
fractions, which are more active that BHA (IC50= 4.8μg/ml), quercetin (IC50=3μg/ml) which are synthetic compounds. From the
antibacterial activity, it appears that the objective extracts and fractions of this plant have a bactericidal activity with respect
to Escherichia coli and Klebsiella pneumoniae. From the results of the chromatographic analysis, it appears that the bark of K.
senegalensis contains glycerol, glycerol ethanoate, pyrocatechol, octadecanamide and neoergosterone as major components.
The diversity of metabolites, the anti-fungal and antibacterial activities of K. senegalensis, could justify the use of this plant in
the veterinary pharmacopoeia in Benin
||plant extracts, metabolites, bactericidal activity, antiradical activity.
||441 - 450